৳ 5/unit
Pack: ৳ 75
৳ 5/unit
Pack: ৳ 75
At a glance
Itopride Hydrochloride is used for gastrointestinal symptoms in chronic gastritis (feeling of an enlarged abdomen, upper abdominal pain, anorexia, heartburn, nausea and vomiting).
Indications
- Gastrointestinal symptoms in chronic gastritis (feeling of an enlarged abdomen, upper abdominal pain, anorexia, heartburn, nausea and vomiting)
Pharmacology
Itopride Hydrochloride is a potent dopamine-2 antagonist and an acetylcholine esterase inhibitor. It increases acetylcholine concentrations by inhibiting dopamine D2 receptors and acetylcholinesterase. Higher acetylcholine increases GI peristalsis, increases the lower esophageal sphincter pressure, stimulates gastric motility, accelerates gastric emptying, and improves gastro-duodenal coordination.
Dosage
Adult Dose (Oral):
- Usual dose: 50 mg three times daily (before meals)
- Dose may be reduced according to age and symptoms
- Elderly: Prone to adverse reactions due to physiological hypo function; close monitoring required
Child Dose: Not recommended in children and adolescents below 18 years
Side effects
Side Effects:
- Shock and anaphylactoid reactions (hypotension, dyspnoea, larynx edema, urticaria, pallor, diaphoresis)
- Hepatic function disorder and jaundice (increased AST, ALT, g-GTP)
Use in pregnancy
Use in Pregnancy: Safety not verified; use only if therapeutic benefits outweigh possible risks considerably.
Precautions & warnings
Precautions:
- Use with caution as it enhances the action of acetylcholine
- Do not use continuously for extended period when no improvement of GI symptoms is observed
- Remove tablet from PTP packaging before ingestion (risk of esophageal mucosa puncture)
- Close observation for shock and anaphylactoid reactions
- Close observation for hepatic function disorder and jaundice
Overdose effects
Overdose: Gastric lavage and symptomatic therapy should be applied.
Storage conditions
Store below 30°C, in a cool and dry place; keep away from light; keep out of reach of children.