Merocil 1gm1gm/vial

Meropenem is an antibiotic that fights bacteria. It is used to treat severe infections of the skin, lungs, stomach, urinary tract, blood and brain (eg. meningitis). It works by killing the bacteria that cause these problems. However, it will not treat a viral infection. Meropenem is commonly used to treat critically ill patients admitted to the hospital. This medicine is given by drip/infusion or by direct injection into a vein, under the supervision of a healthcare professional. The dose depends on what type of infection you have, where it is in the body and how serious it is. You should have your injections at the same time each day to get the most benefit and you should keep on taking this medicine for as long as you are prescribed it, even if your symptoms quickly improve. If you stop taking it too early the infection may return or worsen. Some people may develop side effects like nausea, vomiting, diarrhea, rash or local redness and swelling at the site of injection. These side effects are usually temporary and go away during treatment as your body adjusts to the medicine. Consult your doctor if these side effects bother you or do not go away. Before starting treatment with this medicine, you should tell your doctor if you have epilepsy (seizures), liver or kidney problems or if you are allergic to any antibiotic. While using it, you may be advised blood tests to monitor your blood cell count and kidney function. This medicine is generally regarded as safe to use in pregnancy and breastfeeding if prescribed by your doctor. Meropenem is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.

• Severe bacterial infections

Meropenem is a synthetic carbapenem beta-lactam antibiotic that exerts its bactericidal activity by inhibiting bacterial cell wall synthesis in gm+ve and gm-ve bacteria through binding to several penicillin-binding proteins (PBPs).

Adult Dose: Intravenous Intra-abdominal infections Adult: 1 g 8 hrly via IV inj over approx 3-5 min or infused over approx 15-30 min. Skin and skin structure infections Adult: 500 mg 8 hrly via IV inj over approx 3-5 min or infused over approx 15-30 min. Cystic fibrosis, Meningitis Adult: 2 g 8 hrly infused over approx 15-30 min. Susceptible infections Adult: 0.5-1 g 8 hrly via IV inj over approx 3-5 min or infused over approx 15-30 min. Hepatic impairment: No dosage adjustment needed. Child Dose: Children: IV 60 mg/kg/day, max 3 g/day q8h 120 mg/kg/day meningitis, max 6 g/day q8h Intravenous Intra-abdominal infections Child: >3mth ?50 kg: 20 mg/kg 8 hrly via IV inj over approx 3-5 min or infused over approx 15-30 min. Max: 1000 mg. Skin and skin structure infections Child: >3 mth ?50 kg: 10 mg/kg 8 hrly via IV inj over approx 3-5 min or infused over approx 15-30 min. Max: 500 mg. Cystic fibrosis, Meningitis Child: >3 mth ?50 kg: 40 mg/kg 8 hrly via IV inj over approx 3-5 min or infused over approx 15-30 min. Max: 2 g. Susceptible infections Child: >3 mth ?50 kg: 10 or 20 mg/kg 8 hrly via IV inj over approx 3-5 min or infused over approx 15-30 min. Renal Dose: Renal impairment: CrCl (ml/min) 26-50 Usual dose 12 hrly. 10-25 Half the usual dose 12 hrly. <10 Half the usual dose 24 hrly.

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Meropenem, please consult your doctor.

Common: • Injection site reactions (pain, swelling, redness) • Nausea • Vomiting • Headache • Rash

[CONSULT YOUR DOCTOR] It is not known whether Meropenem alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Meropenem is an antibiotic that's usually only given in the hospital for serious infections. Inform your doctor if you are allergic to penicillin or if you are taking any seizure medication before starting treatment with this medication. Diarrhea may occur as a side effect. Inform your doctor if you develop severe stomach pain or if you find blood in your stools. Your doctor may monitor your kidney function and blood count while you are having treatment with this medication.

Hypersensitivity to meropenem, other carbapenems. History of anaphylactic reaction to β-lactams (e.g. penicillins, cephalosporins).

Increased plasma concentration w/ probenecid. May decrease plasma levels of valproic acid thus, increasing the risk of seizures.

[SAFE] Consuming alcohol with Meropenem does not cause any harmful side effects.

[SAFE IF PRESCRIBED] Meropenem is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

[SAFE IF PRESCRIBED] Meropenem is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[CAUTION] Meropenem should be used with caution in patients with kidney disease. Dose adjustment of Meropenem may be needed. Please consult your doctor. [SAFE IF PRESCRIBED] Meropenem is safe to use in patients with liver disease. No dose adjustment of Meropenem is recommended.

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