৳ 1/unit
Pack: ৳ 1
৳ 1/unit
Pack: ৳ 1
At a glance
Mesalazine is an anti-inflammatory medicine used for ulcerative colitis and Crohn's disease. It reduces inflammation by blocking the production of inflammatory chemical mediators in the intestines.
Indications
- Mild to moderately active ulcerative colitis - treatment and maintenance of remission
- Crohn's disease - maintenance of remission
Pharmacology
Mesalazine reduces mucosal production of arachidonic acid metabolites, blocking both cyclooxygenase and lipoxygenase pathways, reducing prostaglandin production in the colon to decrease inflammation.
Dosage
Adult Dose (Oral):
- Ulcerative colitis (active): Up to 4 g/day in 2-4 divided doses, 6 weeks
- Ulcerative colitis (maintenance): 2 g/day in divided doses
- Crohn's disease (maintenance): 1.2-2.4 g/day in divided doses
Children (5-12 years): Active: 15-20 mg/kg (max 1 g) 3 times daily; Maintenance: 10 mg/kg (max 500 mg) 2-3 times daily
Side effects
Common Side Effects:
- Headache
- Nausea, vomiting
- Diarrhea
- Abdominal pain
- Flatulence
- Pruritus
- Hair loss
- Asthenia, dyspepsia
Use in pregnancy
Use in Pregnancy: Mesalazine may be unsafe during pregnancy (Category C); animal studies have shown harmful effects on the fetus. Use only if benefits outweigh risks.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Pyloric stenosis may cause delayed gastric retention
- Caution in renal dysfunction (nephropathy, interstitial nephritis)
- Caution in liver disease (hepatic failure reported)
- Consult doctor during pregnancy and lactation
Overdose effects
Overdose: prevent GI absorption, correct fluid/electrolyte balance, maintain renal function; no specific antidote.
Storage conditions
Store below 30°C, away from light and moisture; keep out of reach of children.