৳ 25/unit
Pack: ৳ 150
৳ 25/unit
Pack: ৳ 150
At a glance
Methenamine is used for the treatment and prophylaxis of chronic, uncomplicated lower urinary tract infections. It acts by converting to formaldehyde in acidic urine, exhibiting bactericidal activity.
Indications
- Asymptomatic bacteriuria
- Treatment and prophylaxis of chronic, uncomplicated lower urinary tract infections
- Long-term therapy for prevention of recurrent cystitis
- Suppression of urinary infection in patients with indwelling catheters
- Prophylaxis against infection during instrumental procedures
Pharmacology
Methenamine converts to formaldehyde in acidic urine, which exhibits bactericidal activity against both gram-positive and gram-negative bacteria.
Dosage
Adult Dose (Oral):
- Methenamine hippurate: 1000 mg twice daily
- Catheterized patient: 1000 mg three times daily
- Methenamine mandelate: 1000 mg 4 times daily
Children (6-12 years): 0.5-1 g twice daily; >12 years: adult dose
Side effects
Common Side Effects (1-10%):
- Dysuria
- Gastric upset
- Nausea
- Rash
Use in pregnancy
Use in Pregnancy: Methenamine may be unsafe during pregnancy (Category C); animal studies have shown effects on fetus; use only if benefits outweigh risks.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Caution in patients with indwelling urinary catheters
- Caution in conditions where urine acidification is contraindicated or unattainable (e.g., urea-splitting bacteria)
- Not intended for use in upper UTI
- Monitor urinalysis, urine culture, LFT
- Maintain acidic urine
Overdose effects
Overdose: induce vomiting or gastric lavage, activated charcoal; increase fluid intake.
Storage conditions
Store below 30°C, away from light and moisture; keep out of reach of children.