Methsolon 500 IV/IM
500mg/vialRx৳ 600/unit
Pack: ৳ 600
৳ 600/unit
Pack: ৳ 600
At a glance
Methylprednisolone Sodium Succinate is a potent corticosteroid for IV/IM administration used in severe inflammation, allergies, rheumatic disorders, and organ transplant rejection.
Indications
- Endocrine Disorders (Acute Adrenocortical Insufficiency)
- Rheumatic Disorders (Rheumatoid Arthritis, Bursitis, Gout)
- Collagen Diseases (SLE, Dermatomyositis)
- Skin Diseases (Pemphigus, Stevens-Johnson Syndrome)
- Allergies (Bronchial Asthma, Anaphylaxis)
- Ophthalmic Diseases (Iritis, Keratitis, Optic Neuritis)
- Gastrointestinal Diseases (Ulcerative Colitis, Crohn's Disease)
- Respiratory Diseases (Sarcoidosis, Aspiration Pneumonitis)
- Hematologic Disorders (Hemolytic Anemia, ITP)
- Neoplastic Diseases (Leukemias, Lymphomas)
- Edematous States (Nephrotic Syndrome)
- CNS Diseases (Acute Exacerbations of Multiple Sclerosis)
- Organ Transplant Rejection (Acute Allograft Rejection)
Pharmacology
Methylprednisolone Sodium Succinate is a synthetic corticosteroid with mainly glucocorticoid activity. It binds to and activates intracellular glucocorticoid receptors, which modify DNA transcription and protein synthesis. It inhibits leukocyte infiltration at the site of inflammation, interferes with mediators of inflammatory response, and suppresses humoral immune responses.
Dosage
Adult Dose (IV/IM):
- Anti-inflammatory/Immunosuppressive: 10-500 mg daily (250 mg over at least 5 min; 250 mg slowly over at least 30 min)
- High-dose Therapy: 30 mg/kg IV over ≥30 min, repeated every 4-6 hours for 48 hours
- Status Asthmaticus: 40 mg (repeat according to patient response)
- Organ Transplant Rejection: 0.5-1 g daily (for up to 48-72 hours)
- Multiple Sclerosis: 160 mg daily for 3 days
Child Dose:
- 0.5-1.7 mg/kg daily or 5-25 mg/m² daily (6-12 hourly intervals)
- Pulse Therapy: 15-30 mg/kg/dose over >30 min for 3 days
- Status Asthmaticus: 1-4 mg/kg daily for 1-3 days
- Organ Transplant Rejection: 10-20 mg/kg daily for up to 3 days (Max: 1,000 mg daily)
Side effects
Common Side Effects:
- Allergic/hypersensitivity reactions (anaphylaxis, angioedema)
- Cardiovascular (bradycardia, cardiac arrest, hypertension)
- Dermatologic (acne, skin atrophy, impaired wound healing)
- Endocrine (decreased glucose tolerance, Cushingoid state)
- Fluid and Electrolyte (fluid retention, potassium loss)
- Gastrointestinal (peptic ulcer, pancreatitis)
- Musculoskeletal (osteoporosis, muscle weakness, tendon rupture)
- Neurologic/Psychiatric (convulsions, depression, pseudotumor cerebri)
- Ophthalmic (glaucoma, posterior subcapsular cataracts)
Use in pregnancy
Use in Pregnancy (Category C): Corticosteroids are teratogenic in many species. No adequate controlled studies in pregnant women. Use only if potential benefit justifies risk. Infants born to mothers who received corticosteroids during pregnancy should be monitored for hypoadrenalism.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Caution in heart failure, HTN, DM, GI disease, multiple sclerosis, myasthenia gravis
- Caution in acute MI, cataracts, glaucoma, osteoporosis
- Caution in history of seizure disorder, thyroid disease
- Avoid abrupt withdrawal
- Caution in renal and hepatic impairment
- Monitor growth in children
- Caution in pregnancy and lactation
Overdose effects
Acute overdose: Supportive and symptomatic treatment. Chronic overdose: Temporarily reduce dose or introduce alternate-day therapy.
Storage conditions
Protect from light. Store at controlled room temperature 20° to 25°C. Use solution within 48 hours after mixing.