Methsolon 500 IV/IM500mg/vial

• Endocrine Disorders (Acute Adrenocortical Insufficiency)
• Rheumatic Disorders (Rheumatoid Arthritis, Bursitis, Gout)
• Collagen Diseases (SLE, Dermatomyositis)
• Skin Diseases (Pemphigus, Stevens-Johnson Syndrome)
• Allergies (Bronchial Asthma, Anaphylaxis)
• Ophthalmic Diseases (Iritis, Keratitis, Optic Neuritis)
• Gastrointestinal Diseases (Ulcerative Colitis, Crohn's Disease)
• Respiratory Diseases (Sarcoidosis, Aspiration Pneumonitis)
• Hematologic Disorders (Hemolytic Anemia, ITP)
• Neoplastic Diseases (Leukemias, Lymphomas)
• Edematous States (Nephrotic Syndrome)
• CNS Diseases (Acute Exacerbations of Multiple Sclerosis)
• Organ Transplant Rejection (Acute Allograft Rejection)

Adult Dose (IV/IM):

• Anti-inflammatory/Immunosuppressive: 10-500 mg daily (250 mg over at least 5 min; 250 mg slowly over at least 30 min)
• High-dose Therapy: 30 mg/kg IV over ≥30 min, repeated every 4-6 hours for 48 hours
• Status Asthmaticus: 40 mg (repeat according to patient response)
• Organ Transplant Rejection: 0.5-1 g daily (for up to 48-72 hours)
• Multiple Sclerosis: 160 mg daily for 3 days

Child Dose:

• 0.5-1.7 mg/kg daily or 5-25 mg/m² daily (6-12 hourly intervals)
• Pulse Therapy: 15-30 mg/kg/dose over >30 min for 3 days
• Status Asthmaticus: 1-4 mg/kg daily for 1-3 days
• Organ Transplant Rejection: 10-20 mg/kg daily for up to 3 days (Max: 1,000 mg daily)

Common Side Effects:

• Allergic/hypersensitivity reactions (anaphylaxis, angioedema)
• Cardiovascular (bradycardia, cardiac arrest, hypertension)
• Dermatologic (acne, skin atrophy, impaired wound healing)
• Endocrine (decreased glucose tolerance, Cushingoid state)
• Fluid and Electrolyte (fluid retention, potassium loss)
• Gastrointestinal (peptic ulcer, pancreatitis)
• Musculoskeletal (osteoporosis, muscle weakness, tendon rupture)
• Neurologic/Psychiatric (convulsions, depression, pseudotumor cerebri)
• Ophthalmic (glaucoma, posterior subcapsular cataracts)

• Caution in heart failure, HTN, DM, GI disease, multiple sclerosis, myasthenia gravis
• Caution in acute MI, cataracts, glaucoma, osteoporosis
• Caution in history of seizure disorder, thyroid disease
• Avoid abrupt withdrawal
• Caution in renal and hepatic impairment
• Monitor growth in children
• Caution in pregnancy and lactation