৳ 15.87/unit
Pack: ৳ 15.87
৳ 15.87/unit
Pack: ৳ 15.87
At a glance
Metoclopramide Hydrochloride is a prokinetic drug used to treat nausea, vomiting, indigestion, and stomach discomfort.
Indications
- Nausea and vomiting
- Indigestion and heartburn
- Diabetic gastroparesis
- Gastroesophageal reflux disease (GERD)
- Chemotherapy-induced nausea and vomiting
- Postoperative nausea and vomiting
Pharmacology
Metoclopramide blocks dopamine receptors and at higher doses also blocks serotonin receptors. It enhances the response to acetylcholine of tissue in the upper GI tract causing enhanced motility and accelerated gastric emptying. It also increases lower esophageal sphincter tone.
Dosage
Adult Dose (Oral):
- Diabetic Gastric Stasis: 10 mg 4 times daily (2-8 weeks)
- Chemotherapy-induced Nausea: 10 mg (up to 3 times daily, max 5 days)
- GERD: 10-15 mg 4 times daily (max 12 weeks)
- Elderly: 5 mg/dose
Parenteral Dose: 10 mg IM or slow IV (1-2 minutes)
Child Dose: 0.1-0.2 mg/kg IV/IM/PO (6-8 hourly)
Renal Dose: CrCl <40 mL/min: reduce dose by 50%; CrCl <10 mL/min: reduce dose by 75%
Side effects
Common Side Effects:
- Restlessness
- Drowsiness and fatigue
- Headache
- Dysgeusia (taste changes)
Serious Side Effects:
- Tardive Dyskinesia (uncontrolled movements)
- Extrapyramidal Symptoms (EPS)
- Neuroleptic Malignant Syndrome (NMS)
- Depression and suicidal ideation
Use in pregnancy
Use in Pregnancy (Category B): Generally considered safe. Animal studies show low or no adverse effects on developing baby; limited human studies.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Caution while driving (may cause drowsiness and dizziness)
- Avoid alcohol (may cause excessive drowsiness)
- Avoid in patients with Parkinson's Disease
- Caution in epilepsy (may increase seizure frequency)
- Do not use if history of tardive dyskinesia
Overdose effects
Acute overdose may cause drowsiness, confusion, extrapyramidal symptoms, seizures. Symptomatic treatment.
Storage conditions
Store at 20-25°C. Protect from light. Keep out of reach of children.