৳ 593.24/unit
Pack: ৳ 593.24
৳ 593.24/unit
Pack: ৳ 593.24
At a glance
Salmon Calcitonin is a hormone used for the treatment of Paget's disease, hypercalcemia, and postmenopausal osteoporosis. It inhibits osteoclastic bone resorption, reducing bone loss and increasing bone density.
Indications
- Active Paget's disease (non-responsive to alternative treatments)
- Hypercalcemia
- Postmenopausal osteoporosis (>5 years postmenopause)
Pharmacology
Salmon Calcitonin inhibits osteoclastic bone resorption and reduces bone turnover. It decreases tubular reabsorption and promotes renal excretion of Ca, Cl, Na, Mg, K, and phosphate. This reduces bone loss and increases bone mineral density.
Dosage
Adult Dose:
- Hypercalcemia (IV): 10 u/kg in 500 mL NaCl 0.9% slow IV infusion (≥6 hours)
- Hypercalcemia (SC/IM): 4 u/kg every 12 hours; increase to 8 u/kg every 12 hours after 1-2 days; max 8 u/kg every 6 hours
- Paget's disease (SC/IM): 50 u 3 times weekly to 100 u/day
- Postmenopausal osteoporosis (Nasal spray): 200 u/day (alternate nostrils daily)
Side effects
Common Side Effects:
- Runny nose and nasal irritation (nasal spray)
- GI disturbances, dizziness, flushing
- Tingling of hands, skin rash, abdominal pain
- Injection site inflammation
Use in pregnancy
Use in Pregnancy: Animal studies show adverse effects on the fetus; use only if clearly needed; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Perform skin test before initiating therapy
- Caution in heart failure and renal impairment
- Caution in pregnancy, lactation, and children
- Discontinue if nosebleeds or ulceration inside the nose occurs
Overdose effects
Overdose may cause flushing, nausea, vomiting, and dizziness; provide symptomatic and supportive treatment.
Storage conditions
Store at 2-8°C in a refrigerator; keep out of reach of children.