৳ 7.03/unit
Pack: ৳ 7.03
৳ 7.03/unit
Pack: ৳ 7.03
At a glance
Indapamide is a diuretic (water pill) used to treat hypertension (high blood pressure) and salt and fluid retention associated with congestive heart failure.
Indications
- Essential hypertension
- Salt and fluid retention associated with congestive heart failure
Pharmacology
Indapamide is an oral antihypertensive agent. The mechanism of its antihypertensive action is not fully understood, but both vascular and renal actions are involved. It reduces cardiac hypertrophy, reduces arterial wall thickening, prevents accumulation of embryonic fibronectin in coronary vessels, stimulates vasodilator eicosanoid formation through free radical scavenging, and interacts with renal carbonic anhydrase. Its renal site of action is the proximal segment of the distal tubule.
Dosage
Adult Dose (Oral):
- Hypertension: 1.25-2.5 mg once daily (alone or with other antihypertensives)
- Edema: 2.5 mg once daily, increased to 5 mg daily after 1 week if needed
- Take in the morning (to avoid nighttime urination)
Child Dose: Safety & efficacy not established
Side effects
Common Side Effects:
- Dizziness
- Headache
- Fatigue
- Nausea
- Gastrointestinal symptoms
- Muscle cramp
Others: Anorexia, vomiting, constipation, diarrhea, postural hypotension, electrolyte imbalances (hypochloremic alkalosis, hyponatremia, hypokalemia, hyperuricemia), hypersensitivity reactions (skin rashes, cholestatic jaundice, blood dyscrasias)
Use in pregnancy
Use in Pregnancy: Generally considered safe; animal studies show low or no adverse effects; limited human studies; not recommended during pregnancy.
Precautions & warnings
Precautions:
- Indapamide may decrease alertness and affect vision; do not drive if symptoms occur
- Take in the morning to avoid nighttime urination
- Avoid alcohol (may increase dizziness)
- May cause sudden drop of sodium level; avoid low sodium diet
- Monitor blood pressure; notify doctor if it does not lower down
- Notify doctor if dizziness, tiredness, or muscle weakness persists
- Caution in disturbed water/electrolyte balance, diabetes, gout and kidney problems
- Monitoring of potassium and uric acid serum levels recommended
Overdose effects
Overdose: Electrolyte depletion (hyponatremia, hypokalemia), nausea, vomiting, dizziness, hypotension; symptomatic and supportive treatment; gastric lavage should be considered.
Storage conditions
Store in a cool and dry place; protect from light and moisture; keep out of reach of children.