৳ 45/unit
Pack: ৳ 45
৳ 45/unit
Pack: ৳ 45
At a glance
Amikacin is an aminoglycoside antibiotic used for serious Gram-negative bacterial infections. It is effective in septicemia, respiratory tract infections, bone and joint infections, meningitis, skin infections and urinary tract infections.
Indications
Bacterial septicemia (including neonatal sepsis); serious respiratory tract infections; bone and joint infections; CNS infections (including meningitis); skin and soft tissue infections; intra-abdominal infections (including peritonitis); burns and postoperative infections; complicated and recurrent UTIs; gentamicin and tobramycin-resistant infections; staphylococcal infections.
Pharmacology
Amikacin sulfate is a semisynthetic aminoglycoside antibiotic. It binds to the 30S ribosomal subunit of bacteria to inhibit protein synthesis, resulting in stunted bacterial growth and cell death. It also exhibits bactericidal effects by binding to the bacterial cell wall.
Dosage
Adults and children: 15 mg/kg/day in two equally divided doses (equivalent to 500 mg twice daily in adults).
Neonates and premature children: Initial loading dose 10 mg/kg, then 15 mg/kg/day in two equally divided doses.
Life-threatening or Pseudomonas infections: 500 mg every 8 hours (max 1.5 g/day, max total 15 g).
UTIs (non-pseudomonal): 7.5 mg/kg/day in two equally divided doses (250 mg twice daily in adults).
Renal impairment: Reduce dose or increase dosing interval.
Side effects
Common side effects: Increased blood urea, injection site reactions, nausea, vomiting, skin rash, drug fever, headache, paresthesia.
Serious (rare): Hearing loss (tinnitus, vertigo, partial or complete reversible/irreversible deafness), kidney damage, balance disorder, ototoxicity, nephrotoxicity.
Use in pregnancy
Pregnancy Category: D. Amikacin rapidly crosses the placenta into fetal circulation and there is a potential risk of ototoxicity in the fetus. Use only if clearly needed with medical advice.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Concurrent use with myorelaxants may cause respiratory arrest
- Avoid combination with other aminoglycosides (increased ototoxicity and nephrotoxicity)
- Increased ototoxicity risk with fast-acting diuretics (in renal failure)
- Increased nephrotoxicity with cephalosporins or polymyxins
- Do not use during pregnancy (fetal ototoxicity risk)
- Ensure adequate hydration during treatment (to minimize kidney damage)
Overdose effects
In the event of overdose, peritoneal dialysis or hemodialysis will aid in removal of amikacin from the blood.
Storage conditions
Store below 30°C, protected from light and moisture. Keep out of reach of children.