Mircera 50
Rx৳ 7,945/unit
Pack: ৳ 7,945
৳ 7,945/unit
Pack: ৳ 7,945
At a glance
Methoxy Polyethylene Glycol-Epoetin Beta is a long-acting erythropoietin receptor activator used to treat anemia associated with chronic kidney disease.
Indications
- Anemia associated with chronic kidney disease (CKD)
- Anemia in patients on dialysis
- Anemia in patients not on dialysis
Pharmacology
Methoxy polyethylene glycol-epoetin beta is a continuous erythropoietin receptor activator. It binds to the erythropoietin receptor on bone marrow cells to increase red blood cell production. It demonstrates greater activity and increased half-life compared to natural erythropoietin.
Dosage
Adult Dose:
- Patients on Dialysis (Starting): 0.6 mcg/kg, once every two weeks (IV/SC)
- Patients NOT on Dialysis (Starting): 1.2 mcg/kg, once a month (SC); OR 0.6 mcg/kg, once every two weeks (IV/SC)
- Conversion from Other ESAs: Dose is based on the patient's previous weekly dose of epoetin or darbepoetin alfa
- Dose Adjustment: Can be increased or decreased by 25-50% monthly
Pediatric Dose: Safety and efficacy not established in patients under 18 years.
Side effects
Common (>10%):
- Hypertension (13%)
- Diarrhea (11%)
- Nasopharyngitis (11%)
Uncommon (1-10%):
- Headache (9%)
- Upper respiratory tract infection (9%)
- Cough (6%)
- Hypotension (5%)
- Urinary tract infection (5%)
Rare:
- Seizures
- Pure Red Cell Aplasia (PRCA)
- Allergic reactions
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
Use in pregnancy
Use in Pregnancy: There is limited data on use in pregnant women. Animal studies do not indicate harmful effects on pregnancy, embryonal/fetal development, or postnatal development. Use with caution during pregnancy.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Monitor blood pressure closely before, during, and after treatment - ensure adequate control
- Assess iron status and provide iron supplementation if ferritin <100 µg/L or transferrin saturation <20%
- If hemoglobin rises >1 g/dL in any 2-week period, reduce the dose
- If Pure Red Cell Aplasia (PRCA) is diagnosed, discontinue MIRCERA and do not switch to another ESA
- Caution in hemoglobinopathies, seizures, platelet level >500 x 109/L
Overdose effects
Overdose can lead to excessive erythropoiesis (polycythemia). If hemoglobin exceeds 13 g/dL, temporarily withhold the drug. If clinically indicated, phlebotomy may be performed.
Storage conditions
Store in the refrigerator at 2°C to 8°C. Keep the pre-filled syringe in the outer carton to protect from light. Do not freeze. Can be stored at room temperature (below 30°C) for a single period of up to 1 month.