৳ 50/unit
Pack: ৳ 200
৳ 50/unit
Pack: ৳ 200
At a glance
Moxifloxacin is a 4th generation fluoroquinolone antibiotic used for bacterial infections. It inhibits bacterial DNA replication and cell division.
Indications
- Acute bacterial sinusitis
- Acute bacterial exacerbation of chronic bronchitis
- Community acquired pneumonia
- Uncomplicated & complicated skin and skin structure infections
- Complicated intra-abdominal infections
- Pelvic inflammatory disease
- Typhoid fever
- Bacterial conjunctivitis (eye drops)
Pharmacology
Moxifloxacin inhibits topoisomerase II (DNA gyrase) and topoisomerase IV to prevent bacterial DNA replication, transcription and repair, resulting in bacterial cell death.
Dosage
Adult Dose (Oral):
- Acute bacterial sinusitis: 400 mg once daily, 10 days
- Acute exacerbation of chronic bronchitis: 400 mg once daily, 5 days
- Community acquired pneumonia: 400 mg once daily, 7-14 days
- Uncomplicated skin infections: 400 mg once daily, 7 days
- Complicated skin infections: 400 mg once daily, 7-21 days
- Complicated intra-abdominal infections: 400 mg once daily, 5-14 days
- Pelvic inflammatory disease: 400 mg once daily, 14 days
- Typhoid fever: 400 mg once daily, 10-14 days
Eye Drops: 1 drop in affected eye(s) 2 times daily for 7 days
Side effects
Common Side Effects:
- Nausea, vomiting, diarrhea
- Headache, dizziness
- Eye discomfort, dry eye, burning sensation (drops)
Serious: Tendinitis, tendon rupture, QT prolongation
Use in pregnancy
Use in Pregnancy: Moxifloxacin may be unsafe during pregnancy (Category C); animal studies show evidence of fetal harm. Use only if clearly needed.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Discontinue if tendinitis or tendon pain occurs
- Risk of QT prolongation; correct electrolyte imbalances
- Caution in myasthenia gravis
- Safety not established in patients <18 years
- Caution during pregnancy and lactation
- Caution when driving (may cause dizziness)
Overdose effects
Overdose: Nausea, vomiting, diarrhea, dizziness; symptomatic treatment.
Storage conditions
Store in a dry place, away from light and heat; keep out of reach of children.