৳ 1/unit
Pack: ৳ 1
৳ 1/unit
Pack: ৳ 1
At a glance
Nitrazepam is a benzodiazepine used for insomnia. It enhances the inhibitory effect of GABA to suppress abnormal and excessive activity of nerve cells in the brain, inducing sleep.
Indications
- Disturbances of sleep of various etiology
- Insomnia of neurotics
- Involutional restlessness
- Sleep disturbances in cerebrosclerotic patients
- Myoclonic seizures
Pharmacology
Nitrazepam enhances the inhibitory effect of GABA to prevent excessive brain cell activity, depressing the reticular-activating system in the brainstem to induce sleep.
Dosage
Adult Dose (Oral):
- 5 mg at night; increase to 10 mg if necessary
Elderly and Debilitated: Half of normal adult dose
Pediatric Dose (Myoclonic seizures):
- 0.3-1.0 mg/kg/day in 3 divided doses
Side effects
Common Side Effects:
- Dizziness
- Sedation
- Drowsiness
- Unsteadiness
- Impaired coordination
Use in pregnancy
Use in Pregnancy: Nitrazepam is highly unsafe during pregnancy; definite evidence of fetal harm. Not recommended in first 3 months.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Should not be used for more than 4 weeks
- High addiction/habit-forming potential
- Do not stop suddenly (withdrawal symptoms may occur)
- Caution while driving
- Avoid alcohol
- Elderly patients may have reduced muscle tone and increased risk of falls
Overdose effects
Overdose: Somnolence, confusion, ataxia, coma, dyspnoea, hypotension, respiratory and cardiovascular depression; gastric lavage, flumazenil treatment.
Storage conditions
Store at room temperature; protect from light and moisture; keep out of reach of children.