Neokit
20mg+400mg+500mgRx৳ 770/unit
Pack: ৳ 770
৳ 770/unit
Pack: ৳ 770
At a glance
Omeprazole + Metronidazole + Clarithromycin is a triple therapy kit used for the treatment of H. pylori infection. Omeprazole reduces stomach acid, Metronidazole and Clarithromycin are antibiotics that kill H. pylori bacteria.
Indications
H. pylori infection (associated with peptic ulcer disease).
Pharmacology
Omeprazole inhibits the final step of gastric acid secretion by blocking the H+/K+ ATPase enzyme system in gastric parietal cells. Metronidazole is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand breakage, leading to protein synthesis inhibition and cell death. Clarithromycin inhibits protein synthesis by penetrating the cell wall and binding to 50S ribosomal subunits.
Dosage
Adult Dose: Twice daily (morning and evening) for 7-14 days. Each kit contains: Omeprazole 20 mg + Clarithromycin 250 mg + Metronidazole 400 mg.
Side effects
Common side effects: Nausea, vomiting, diarrhea, abdominal pain, headache, dizziness, dry mouth, dark stools, stomatitis, myalgia, confusion, vaginitis.
Serious side effects: Allergic reactions (rash, itching, swelling of face, difficulty breathing), severe diarrhea, liver problems (jaundice, dark urine), QT prolongation (irregular heartbeat).
Use in pregnancy
Unsafe during pregnancy. Use only if clearly needed under medical supervision.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Serious and occasional hypersensitivity reactions may occur (especially in patients with history of penicillin allergy). Elderly patients have higher risk of hepatic and renal impairment. Avoid alcohol during treatment. Unsafe during pregnancy. Complete the full course even if you feel better.
Overdose effects
Symptoms of overdose: nausea, vomiting, diarrhea, headache, dizziness, confusion. Seek medical attention immediately if overdose is suspected.
Storage conditions
Store below 30°C in a cool and dry place, protected from light. Keep out of reach of children.