৳ 4/unit
Pack: ৳ 4
৳ 4/unit
Pack: ৳ 4
At a glance
Nicorandil is a vasodilator used for prevention and long-term treatment of angina pectoris. It opens potassium channels to dilate arterioles and stimulates guanylate cyclase causing venous vasodilatation, reducing preload and afterload and improving coronary blood flow.
Indications
- Prevention and long-term treatment of angina pectoris
Pharmacology
Nicorandil opens potassium channels to dilate arterioles and coronary arteries, and stimulates guanylate cyclase to cause venous vasodilatation, reducing preload and afterload and improving coronary blood flow.
Dosage
Adult Dose (Oral):
- Initial: 10 mg twice daily; may increase to 20 mg twice daily
- For patients prone to headache: 5 mg twice daily
- Max dose: 30 mg twice daily
Side effects
Common Side Effects:
- Headache (especially on initiation, usually transitory)
- Cutaneous vasodilation with flushing
- Nausea, vomiting
- Dizziness, weakness
- Rare: oral ulceration, myalgia
- At high dosage: reduction in blood pressure and/or increase in heart rate
- Angioedema
Use in pregnancy
Use in Pregnancy: Nicorandil may be unsafe during pregnancy; animal studies show evidence of fetal harm.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Caution in hypovolaemia, low systolic BP, acute pulmonary oedema, glaucoma
- May impair ability to drive or operate machinery
- Discontinue if mouth ulceration or stomatitis appears
- Avoid alcohol
Overdose effects
Overdose: Peripheral vasodilation, fall in blood pressure and reflex tachycardia; monitor cardiac function, supportive measures, fluid replacement, vasopressors.
Storage conditions
Store in a cool and dry place, protected from light; keep out of reach of children.