Nidocard RETARD 2.6

• Stable angina
• Acute relief of angina pectoris
• Prophylaxis of angina
• Acute myocardial infarction
• Control of hypertension during surgery

Glyceryl trinitrate acts on the enzyme nitric oxide stimulating guanylate cyclase in the vascular smooth muscle cells resulting in the relaxation of smooth muscles. It reduces venous return (preload) and facilitates subendocardial blood flow with redistribution into ischaemic areas. It relieves coronary vasospasm and dilates arterioles reducing afterload. It is useful for relief and prevention of anginal attacks.

Oral (SR Tab/Cap):

• 2.6-6.4 mg 3-4 times daily, adjust according to response
• Maximum: 26 mg 4 times daily

Sublingual Tablet (Acute Relief):

• 0.5 mg SL q5min up to 3 times
• Use at first sign of angina

Sublingual Tablet (Prophylaxis):

• 1 tablet 5-10 minutes before activities likely to provoke angina

Sublingual Spray:

• 1-2 spray(s) PRN for angina, may repeat q3-5min, not to exceed 3 sprays in 15 minutes

Intravenous (Acute MI):

• 10-100 mcg/min

* Use as directed by the registered physician

Common Side Effects:

• Headache (may be severe)
• Dizziness
• Lightheadedness
• Decreased blood pressure
• Increased heart rate
• Blurred vision
• Paresthesia

Use in Pregnancy: Generally considered safe during pregnancy. Animal studies have shown low or no adverse effects.

Precautions:

• Headache usually goes away after a few days - inform doctor if it persists.
• Tolerance may develop - follow prescribed dosing schedule.
• May cause dizziness or sleepiness - do not drive.
• Avoid alcohol (increases dizziness).
• Do not use with sildenafil or tadalafil (may cause hypotension).

Overdose: Overdose may cause severe hypotension, headache, dizziness, nausea, diarrhea. Supportive care should be given.

Storage: Keep below 30°C, away from light and moisture. Keep out of reach of children.