Nocpres 100

Desmopressin is a medicine used in the treatment of diabetes insipidus and bed-wetting. It helps decrease the urge to urinate and help resume more normal life-style. Desmopressin can be taken in an empty stomach or after food. Your doctor will decide the dose and how often you should take them. You should use it regularly to get the most benefit from the medicine. Do not stop using the medicine even if you feel better unless the doctor tells you so. Some common side effects of this medicine include headache, stomach pain, and nausea. Let your doctor know if any of these side effects do not go away or get worse. Before using this medicine, inform your doctor if you have any problems with your heart, liver, or kidneys. You should also tell your doctor all the other medicines you are taking. Your doctor may monitor your blood glucose regularly while on treatment with this medicine. Desmopressin is a synthetic form of vasopressin (natural hormone that balances water). It works by causing reabsorption of water from the kidneys which controls excessive thirst and urination in diabetes insipidus. It also helps decrease night-time urine production and bedwetting in children. In addition to these, it reduces bleeding episodes by promoting the release of blood clotting factors.

• Diabetes insipidus • Bed-wetting

Desmopressin increases cyclic adenosine monophosphate (cAMP) in renal tubular cells which increases water permeability resulting in reduced urine volume and enhanced urine osmolality. It also stimulates factor VII and plasminogen activator activity in the blood, but w/ minimal pressor activity. Onset: Antidiuretic: Approx 60 min (oral); 15-30 min (intranasal).

Adult Dose: Diabetes Insipidus Intranasal Indicated as antidiuretic replacement therapy in the management of central cranial diabetes insipidus and for management of the temporary polyuria and polydipsia following head trauma or surgery 10-40 mcg (0.1-0.4 mL) qDay, either as a single dose or divided into 2 or 3 doses; usual dose is 20 mcg (0.2 mL) qDay in 2 divided doses Adjust morning and evening doses separately for an adequate diurnal rhythm of water turnover PO Initial: 0.05 mg q12hr Effective range: 0.1-1.2 mg divided q8-12hr Observe fluid restriction If switching to PO from intranasal, start PO at least 12 hours after last intranasal dose IV/SC 2-4 mcg/day divided q12hr or one-tenth the maintenance of intranasal dose Hemophilia A IV Indicated for patients with hemophilia A with factor VIII coagulant activity levels greater than 5% 0.3 mcg/kg IV over 15-30 minutes (for pre-op, 30 min before procedure) Intranasal Indicated for patients with mild to moderate classic von Willebrand disease (Type I) with Factor VIII levels >5% 50 kg: 300 mcg; for pre-op, give 2 hr before procedure Von Willebrand Disease (Type 1) IV Indicated for patients with mild to moderate classic von Willebrand’s disease (Type I) with factor VIII levels greater than 5% 0.3 mcg/kg IV over 15-30 minutes (for pre-op, 30 min before procedure) Intranasal Indicated for patients with mild to moderate classic von Willebrand disease (Type I) with Factor VIII levels >5% 50 kg: 300 mcg; for pre-op, give 2 hr before procedure Nocturnal Enuresis Primary nocturnal enuresis (not intranasal) 0.2 mg PO qHS (up to 0.6 mg/day) Nocturia Nocturnal polyuria was defined in clinical trials as nighttime urine production exceeding one-third of 24-hour urine production Preservative-free nasal spray Indicated for nocturia due to nocturnal polyuria in adults who awaken at least 2 times per night to void >50 to 65 years 0.83 mcg in either nostril nightly ~ 30 min before going to bed; 0.83 mcg dose may have a lower risk of hyponatremia; may be increased to 1 spray of 1.66 mcg after at least 7 days, if needed, provided serum sodium has remained normal Sublingual tablets Indicated for nocturia due to nocturnal polyuria in adults who awaken at least 2 times per night to void Before starting or resuming, assess the sodium concentration and only start or resume in patients with a normal serum sodium concentration Women: 27.7 mcg SL qDay, 1 hr before bedtime, administered SL without water Men: 55.3 mcg SL qDay, 1 hr before bedtime, administered SL without water Uremic Bleeding in Acute or Chronic Renal Failure 0.4 mcg/kg IV over 10 minutes Child Dose: Diabetes Insipidus Nasal spray Indicated as antidiuretic replacement therapy in the management of central cranial diabetes insipidus and for management of the temporary polyuria and polydipsia following head trauma or surgery in the pituitary region in patients (>3 months) 12 years 10-40 mcg (0.1-0.4 mL) qDay, either as a single dose or divided into 2 or 3 doses; usual dose is 20 mcg (0.2 mL) qDay in 2 divided doses Adjust morning and evening doses separately for an adequate diurnal rhythm of water turnover Nocturnal Enuresis >6 years: 0.2 mg PO qHS (up to 0.6 mg/day) Hemophilia A & Von Willebrand Disease Indicated for patients with hemophilia A or von Willebrand disease (type 1) with Factor VIII coagulant activity levels >5%; will also stop bleeding in patients with episodes of spontaneous or trauma-induced injuries (eg, hemarthroses, intramuscular hematomas, mucosal bleeding) IV Infants >3 months, children, and adolescents 0.3 mcg/kg IV If used preoperatively, administer 30 min before procedure May repeat dose if needed Intranasal Infants >11 months, children, and adolescents 50 kg: 300 mcg intranasally If used preoperatively, administer 2 hr before procedure Fluid intake should be limited 1 hr prior to dose until the next morning or at least 8 hr after administration Repeat use determined by clinical symptoms and laboratory values Renal Dose: Renal impairment CrCl 50 mL/min: No adjustments necessary

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Desmopressin may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Desmopressin, skip it and continue with your normal schedule. Do not double the dose.

Common: • Headache • Nausea

[SAFE] Desmopressin does not usually affect your ability to drive. You have been prescribed Desmopressin for the treatment of diabetes insipidus and/or bed-wetting. Limit the amount of fluids you drink with this medication. Desmopressin can cause low sodium levels in your body. Get regular blood tests done to monitor the levels. Inform your doctor if you develop an infection, fever, diarrhea, or vomiting. Talk to your doctor if you have sudden weight gain or swelling in your arms and legs that does not go away.

Cardiac insufficiency w/ ongoing diuretic treatment. Patient w/ habitual and psychogenic polydipsia, hyponatraemia or history of hyponatraemia. Moderate to severe renal impairment (CrCl <50 mL/min).

May enhance antidiuretic effect w/ NSAIDs (e.g. ibuprofen), indometacin, TCAs, chlorpromazine, carbamazepine, SSRIs, opiates, lamotrigine. May reduce antidiuretic effect w/ lithium, epinephrine (large dose), heparin, demeclocycline.

[UNSAFE] It is unsafe to consume alcohol with Desmopressin.

[SAFE IF PRESCRIBED] Desmopressin is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

[SAFE IF PRESCRIBED] Desmopressin is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

[CONSULT YOUR DOCTOR] There is limited information available on the use of Desmopressin in patients with kidney disease. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Desmopressin in patients with liver disease. Please consult your doctor.

I have diabities insipidus. I have use regularly minirin nasal spray for last 6 -7 years. Any other alternate of these spray or any other treatment. This spray is also costly. Pl help me. 9XXXXXX Tablet form us also available. Bed wetting every night help pl Any medicine for bed wetting There are many underlying causes of your symptoms. Specific treatment can not be given unless we establish exact underlying cause. Please consult Pediatrician. will take detail history and will examine your child in detail. At time may ask you relevant investigations if necessary. All information will be used to determine exact underlying cause of problem. Depending upon cause will prescribe you treatment. Bed wetting i.e.urine at bed during night U need to see paediatrician near by Bed wetting in night since 1.5year My baby every night bed wetting pl explain. Reasons. Generally, bed-wetting before age 7 isn&#x27;t a concern. At this age, your child may still be developing nighttime bladder control. Most children outgrow bed-wetting on their own ? but some need a little help. In other cases, bed-wetting may be a sign of an underlying condition that needs medical attention. Consult your child&#x27;s doctor if: Your child still wets the bed after age 7 Your child starts to wet the bed after a few months or more of being dry at night Bed-wetting is accompanied by painful urination, unusual thirst, pink or red urine, hard stools, or snoring Children Bed Wetting Treatment Bed wetting Generally, bed-wetting before age 7 isn&#x27;t a concern. At this age, your child may still be developing nighttime bladder control. Most children outgrow bed-wetting on their own ? but some need a little help. In other cases, bed-wetting may be a sign of an underlying condition that needs medical attention. Consult your child&#x27;s doctor if: Your child still wets the bed after age 7 Your child starts to wet the bed after a few months or more of being dry at night Bed-wetting is accompanied by painful urination, unusual thirst, pink or red urine, hard stools, or snoring Bed wetting during sleep at night Generally, bed-wetting before age 7 isn&#x27;t a concern. At this age, your child may still be developing nighttime bladder control. Most children outgrow bed-wetting on their own ? but some need a little help. In other cases, bed-wetting may be a sign of an underlying condition that needs medical attention. Consult your child&#x27;s doctor if: ?Your child still wets the bed after age 7 ?Your child starts to wet the bed after a few months or more of being dry at night ?Bed-wetting is accompanied by painful urination, unusual thirst, pink or red urine, hard stools, or snoring bed wetting problem in a night Please elaborate your symptoms, history, treatment and investigations done. has the problem of bed wetting Hi Kindly consult to Ayurvedic doctor at your local city area , face to face consult is needed.