৳ 2.50/unit
Pack: ৳ 2.50
৳ 2.50/unit
Pack: ৳ 2.50
At a glance
Carbocisteine is a mucolytic medication used in the treatment of various respiratory tract disorders associated with excessive mucus. It thins and loosens mucus (phlegm) in the nose, windpipe, and lungs, making it easier to cough out.
Indications
- Upper respiratory inflammation (pharyngitis, laryngitis) - expectoration
- Acute bronchitis
- Bronchial asthma
- Chronic bronchitis
- Bronchiectasis
- Pulmonary tuberculosis
- Drainage in chronic sinusitis
- Drainage in otitis media with effusion
Pharmacology
Carbocisteine reduces the viscosity of non-infected secretions from mucous cells in the respiratory tract. It breaks disulphide bonds cross-linking glycoprotein molecules in mucus and alters local ionic charges, both affecting mucus viscosity. It also alters mucin composition, decreasing neutral glycopeptides and increasing sialoglycopeptides.
Dosage
Adults (including elderly): Initial dose: 2250 mg/day (750 mg 3 times daily) in divided doses. After satisfactory response: 1500 mg/day (375 mg 4 times daily) in divided doses.
Children: Normal daily dose: 20 mg/kg body weight/day (in divided doses).
2-5 years: 62.5-125 mg 4 times daily.
6-12 years: 250 mg 3 times daily.
Infants: Dosage not established.
Note: Do not use without medical advice.
Side effects
- Gastrointestinal discomfort
- Nausea
- Diarrhea
- Gastrointestinal bleeding (rare)
- Headache
- Skin rash
- Facial swelling (rare)
- Allergic reaction
- Breathlessness
- Wheezing
Use in pregnancy
Adequate information on use during pregnancy is not available. No teratogenic effects reported in animal studies, but use is not recommended during the first trimester of pregnancy.
Precautions & warnings
- Use with caution in patients with recent history of peptic ulcer or recurrent gastrointestinal bleeding.
- Not recommended during the first trimester of pregnancy.
- Limited information on use in liver and kidney disease; caution required.
- Avoid alcohol consumption.
- Know your response before driving (may cause dizziness).
Overdose effects
Overdose may cause nausea, vomiting, diarrhea. Consult your doctor if overdose is suspected.
Storage conditions
Store below 30°C, away from light and moisture. Keep out of reach of children.