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Disopyramide is a medicine used to treat arrhythmia (abnormal heart rhythm). It restores normal heart rhythm by blocking abnormal electrical signals in the heart. This helps to maintain a regular and steady heartbeat. Disopyramide should be taken regularly as advised by the doctor. You may take it without food but it is better to take this medicine at a fixed time. This medicine should not be stopped abruptly without consulting the doctor as this can worsen your condition. Regular follow-up with your doctor is advised while using this medicine. Side effects like constipation, dryness in mouth, urinary retention and blurred vision may be seen in some patients. This medicine may also lead to worsening of heart function and low blood pressure in patients with pre-existing heart disease. Your doctor may advise for regular monitoring of blood sugar levels and kidney function while you are taking this medicine. This medicine may not be suitable for some people. You must inform the doctor if you are suffering from any heart, liver or kidney disease. Also, let your doctor know about all the other medications that you are using regularly. This medicine is not usually recommended during pregnancy or breastfeeding, so always consult your doctor before taking it. Disopyramide is an anti-arrhythmic medication. It works by blocking abnormal electrical signals in the heart to correct irregular heartbeat to a normal rhythm.

• Arrhythmia

Disopyramide is a Ia antiarrhythmic agent which acts by decreasing myocardial excitability and conduction velocity. It lengthens the effective refractory period of the atrium. It also possesses antimuscarinic and negative inotropic effects.

Adult Dose: Oral Supraventricular and ventricular arrhythmias Adult: 300-800 mg daily in divided doses (as conventional capsules every 6 hr), adjusted according to patient's response. Hepatic impairment: 400 mg daily in divided doses. Liver cirrhosis: consider a therapeutic range 50% lower than in patients with normal hepatic function. Child Dose: Oral Ventricular Arrhythmias <1 year old: 10-30 mg/kg/day divided q6hr PO 1-4 years old: 10-20 mg/kg/day divided q6hr PO 4-12 years old: 10-15 mg/kg/day divided q6hr PO 12-18 years old: 6-15 mg/kg/day divided q6hr PO Renal Dose: Renal impairment: CrCl (ml/min) >40 400 mg daily in divided doses. 30-40 100 mg every 8 hr; avoid modified release preparations. 15-30 100 mg every 12 hr; avoid modified release preparations. <15 100 mg every 24 hr; avoid modified release preparations.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Disopyramide is to be taken empty stomach.

If you miss a dose of Disopyramide, skip it and continue with your normal schedule. Do not double the dose.

Common: • Blurred vision • Worsening of pre-existing glaucoma • Constipation • Dryness in mouth • Urinary retention

[UNSAFE] Disopyramide may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. It may cause dizziness. Do not drive or perform activities require mental focus until you know how it affects you. Do not start any medicine including prescription or over-the-counter medicines without informing your doctor, as they may alter Disopyramide levels in your body. Your doctor may get blood tests done to check your sodium and potassium levels, kidney function, and lung function before starting treatment with this medicine. Your doctor may regularly monitor blood sugar level while taking this medicine. Inform your doctor if you experience slow or fast heart rate, chest pain, shortness of breath. Inform your doctor if you are pregnant or planning to conceive or breastfeeding. Do not stop taking medication suddenly without talking to your doctor.

Patients with complete heart block; glaucoma; predisposition to urinary retention; myasthenia gravis. Sinus node disease in absence of pacemaker. Cardiomyopathy. Cardiogenic shock. Hypotension. Hypersensitivity. Children.

Avoid other Class I antiarrhythmics and other cardiac depressants including beta-blockers except in life-threatening arrhythmias. Risk of worsening of arrhythmias, precipitation of new arrhythmias and ventricular fibrillation when used with other anti-arrhythmics. Reduced efficacy when co-admin with phenytoin. Potentially Fatal: Enhanced antimuscarinic effects with other antimuscarinic drugs. Potentiates negative chronotropic and inotropic effects of ?-blockers and verapamil. Potentiates inhibitory effect on the conduction system produced by digitalis. Potentiates QT interval prolongation produced by TCAs and amiodarone.

[CAUTION] Caution is advised when consuming alcohol with Disopyramide. Please consult your doctor.

[CONSULT YOUR DOCTOR] Disopyramide may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Disopyramide is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[CAUTION] Disopyramide should be used with caution in patients with kidney disease. Dose adjustment of Disopyramide may be needed. Please consult your doctor. [CAUTION] Disopyramide should be used with caution in patients with liver disease. Dose adjustment of Disopyramide may be needed. Please consult your doctor.

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