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At a glance

Oxybuprocaine Hydrochloride 0.4% Eye prep is a local anaesthetic used to temporarily numb the front surface of the eye for tonometry or foreign body removal.

Indications
  • Local ocular anaesthesia
  • Tonometry (eye pressure measurement)
  • Contact lens fitting
  • Foreign body removal from corneal epithelium
  • Incision of meibomian cyst
Pharmacology

Oxybuprocaine blocks sodium channels to prevent neuronal membrane depolarization, blocking initiation and conduction of nerve impulses and producing local anaesthesia.

Dosage

Adult Dose (Eye Drops):

  • Tonometry: 1 drop in conjunctival sac, after 60 seconds
  • Contact lens fitting: 1 drop, another drop after 90 seconds
  • Foreign body removal/cyst incision: 3 drops at 90-second intervals, sufficient anaesthesia after 5 minutes
Side effects

Side Effects:

  • Hypersensitivity reactions
  • Transient stinging and blurring of vision
  • CNS excitation
  • Muscle twitching and tremors
  • Convulsions
Use in pregnancy

Use in Pregnancy: Oxybuprocaine may be unsafe during pregnancy (Category C); use only if potential benefit justifies potential risk.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Caution in heart block, epilepsy, impaired cardiac conduction, myasthenia gravis
  • Do not apply to inflamed, infected tissues or damaged mucosa
  • Protect anaesthetised eye from dust and bacterial contamination
  • Cornea may be damaged by prolonged application
  • Do not drive until normal vision restored
Overdose effects

Overdose may cause CNS excitation, convulsions; symptomatic treatment.

Storage conditions

Store in a cool and dry place, away from light; keep out of reach of children.

Oxybuprocaine Hydrochloride 0.4% Eye prep — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.