Ofuran500mg/100ml
Rx- Generic:
- Nitrofurantoin
- Company:
- Pacific Pharmaceuticals Ltd.
- Dosage form:
- Suspension
- Pack size:
- Suspension
৳ 1/unit
Pack: ৳ 1
At a glance
Nitrofurantoin — brands, prices, indication, dosage and side effects available in Bangladesh.
Description
Nitrofurantoin is an antibiotic that fights bacteria. It is used to treat and prevent uncomplicated urinary tract infections. It works by killing the bacteria that cause such disease. But, it will not treat a viral infection. Nitrofurantoin should be taken in the dose and duration as advised by the doctor. You may take it with food to avoid nausea, which is a common side effect. It is better to have this medicine at the same time each day to get the most benefit and you should keep on taking this medicine for as long as you are prescribed it, even if your symptoms quickly improve. If you stop taking it too early the infection may return or worsen. Some people may develop side effects like nausea, vomiting, and diarrhea. These side effects are usually temporary and go away during treatment as your body adjusts to the medicine. Consult your doctor if these side effects bother you or do not go away. This medicine may turn your urine into dark yellow or brown color. But, this is normal and nothing to worry about. Before starting treatment with this medicine, you should tell your doctor if you are pregnant, breastfeeding or suffering from any liver, kidney or heart problems or if you are allergic to any antibiotic. Nitrofurantoin is an antibiotic. It works by killing the bacteria in the urine that causes infection.
Indications
• Bacterial infections of urinary tract
Mechanism of action
Nitrofurantoin interferes with cell metabolism and cell wall synthesis by inhibiting several enzyme systems including acetyl coenzyme A. It is bactericidal to most gram-positive and gram-negative urinary tract pathogens.
Dosage
Adult Dose: Oral Acute uncomplicated urinary tract infections Adult: 50-100 mg 4 times daily for 7 days or for 3 days after obtaining sterile urine. SR preparation: 100 mg bid for 7 days or for 3 days after obtaining sterile urine. Prophylaxis of uncomplicated urinary tract infections Adult: 50-100 mg at bedtime for up to 12 months. Child Dose: Urinary Tract Infection >1 month 5-7 mg/kg/day PO divided q6hr for 7 days UTI prophylaxis: 1-2 mg/kg PO qHS or 2 divided doses >12 years 50-100 mg PO q6hr for 7 days or for 3 days after obtaining sterile urine SR preparation: 100 mg PO q12hr for 7 days or for 3 days after obtaining sterile urine Long-term prophylaxis/suppression: 50-100 mg PO at bedtime for up to 12 months Renal Dose: Loses effectiveness in patients with CrCl <60 mL/min due to inadequate urine concentration Monitor renal function; renally excreted; decreased renal function more likely in elderly
Administration
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nitrofurantoin is to be taken with food.
Missed dose
If you miss a dose of Nitrofurantoin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Side effects
Common: • Nausea • Vomiting • Diarrhea
Precautions & warnings
[UNSAFE] Nitrofurantoin may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Niftas Tablet SR treats and prevents uncomplicated urinary tract infections. Finish the prescribed course of the medicine, even if you start to feel better. Stopping it early may make the infection come back and harder to treat. Take it with food to avoid nausea, which is a common side effect. It can turn your urine a dark yellow or brown colour. This is normal and nothing to worry about. Do not take it for longer or more often than prescribed by your doctor.
Contraindications
Severe renal impairment (anuria, oliguria, significantly elevated serum creatinine, CrCl <60 ml/min). Hypersensitivity to nitrofurans, G6PD deficiency, infants <3 mth. Pregnancy at term, during labour and delivery, or when the onset of labour is imminent.
Drug interactions
Reduced excretion with probenecid or sulfinpyrazone. Absorption reduced by magnesium trisilicate. Antagonistic effects with quinolone antibacterials. Reduced effects with carbonic anhydrase inhibitors or urinary alkalinisers.
Food interactions
[UNSAFE] Consuming alcohol while taking Nitrofurantoin may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
Use in pregnancy
[SAFE IF PRESCRIBED] Nitrofurantoin is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Use in lactation
[CAUTION] Nitrofurantoin should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.
Renal / hepatic impairment
[CAUTION] Nitrofurantoin should be used with caution in patients with kidney disease. Dose adjustment of Nitrofurantoin may be needed. Please consult your doctor. Use of Nitrofurantoin is not recommended in patients with severe kidney disease, who are unable to pass urine or have high creatinine levels. [CAUTION] Nitrofurantoin should be used with caution in patients with liver disease. Dose adjustment of Nitrofurantoin may be needed. Please consult your doctor. Use of Nitrofurantoin is not recommended in patients with severe liver disease and active liver disease.
Common questions
Prostrate check up Urinary tract infections Needs antibiotics Meet a urologist UTI in vagina.pain and burning sensation in bladder and vagina. Taken Urispas and Alkacid.no relief. Suggest a quick action medicine. Start tab niftas 100 mg twice a day for 7 days .apply quadriderm oint. Having urine infection since about a month. Took several antibiotics after consultation with doctor but they all show effect only for starting 2 days and then that antibiotic doesn't work. I have taken sporidex 500, zefu cv 500, norflox 400, levofloxin, cefodoxime (each taken for atleast 4-5 days). All work for starting two days then no effect and infection starts to increase. Urine culture report is attached. Kindly suggest medication since problem is increasing day by day. You should consult a urologist and get a few tests done since we need to know the cause of your recurrent urinary tract infections. She has alway Urinary tract infections, and bed wetting problem. How to control over it. Syrup Cystone 10 ml twice a day after food for 2 months. Training to avoid bed wetting to be given 8 mm stone in kidney during pregnancy Nothing needs to be done for this. Take plenty of fluids. It can lead to sudden colicky pain or can predispose to frequent urinary tract infections Repeated urinary tract infections from last 10 year's Please give best treatment complete prevention for urine infection I am suffering from urinary tract infections from last 10 year's, when I use antibiotics then cure temporarily, after some days it will repeat automatically Get urine routine examination n culture n ultrasound kub with PVR Gall bladder/urinary tract stones U will require surgery to remove bladder n right vuj calculus. For gall bladder stones consult general or gastro surgeon Kidney Stone in Right kidney of 5 mm size , blood in urine , scanty urine , pain in abdomen , urinary tract pain Take Tablet neeri 2 tab twice, chandraprabha vati 2 tablet twice with water