৳ 2.50/unit
Pack: ৳ 2.50
৳ 2.50/unit
Pack: ৳ 2.50
At a glance
Olanzapine is an atypical antipsychotic used for schizophrenia and mania in bipolar disorder. It blocks dopamine and serotonin receptors to improve mood, thoughts and behavior.
Indications
- Schizophrenia and related psychoses (positive and negative symptoms)
- Acute manic or mixed episodes in bipolar disorder
Pharmacology
Olanzapine blocks dopamine D2 and serotonin 5HT2A receptors to help control mood, thoughts and behavior. It also has affinity for other receptors contributing to its side effect profile.
Dosage
Adult Dose (Oral):
- Schizophrenia: 5-10 mg/day (initial); increase by 5 mg/day weekly; maintenance: 10-20 mg/day; max 20 mg/day
- Mania (monotherapy): 10-15 mg/day (initial); 5-20 mg/day (maintenance)
- Mania (with lithium/valproate): 10 mg/day (initial); 5-20 mg/day (maintenance)
- Hepatic/Renal impairment: 5 mg/day (initial)
Pediatric Dose (13-17 years): 2.5-5 mg/day (initial); target 10 mg/day; range 2.5-20 mg/day
Side effects
Common Side Effects:
- Somnolence
- Weight gain
- Increased appetite
- Elevated glucose and triglyceride levels
- Dizziness
- Akathisia
- Parkinsonism
- Dyskinesia
- Orthostatic hypotension
- Constipation and dry mouth
- Asthenia, edema, photosensitivity
Use in pregnancy
Use in Pregnancy: Olanzapine may be unsafe during pregnancy; animal studies show evidence of fetal harm.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Do not stop suddenly (may worsen symptoms)
- Caution in history of seizures
- Caution in low leukocyte/neutrophil counts
- Caution in hepatic impairment
- Caution while driving (may cause drowsiness and dizziness)
- Avoid alcohol
Overdose effects
Overdose: Somnolence, confusion, ataxia, tachycardia, hypotension, seizures; symptomatic treatment.
Storage conditions
Store below 30°C; protect from light & moisture; keep out of reach of children.