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Ceftibuten is an antibiotic medicine used to treat bacterial infections in your body. It is effective in infections of the lungs (eg. pneumonia), urinary tract, ear, nasal sinus, and throat. It kills bacteria, which helps to improve your symptoms and cure the infection. Ceftibuten may be taken with or without food. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you to remember to take it. The dose will depend on what you are being treated for, but you should always complete a full course of this antibiotic as prescribed by your doctor. Do not stop taking it until you have finished, even when you feel better. If you stop taking it early, some bacteria may survive and the infection may come back. It will not work for viral infections such as flu or the common cold. Using any antibiotic when you do not need it can make it less effective for future infections. The most common side effects of this medicine include vomiting, allergic reaction, stomach pain and diarrhea. Taking this medicine along with some food may help to prevent indigestion and upset stomach. Seek emergency medical help if you get a rash, itchy skin, swelling of face and mouth, or have difficulty breathing. Before using it, you should tell your doctor if you are allergic to any antibiotics or have any kidney or liver problems. Pregnant and breastfeeding mothers should consult their doctor before using it. Ceftibuten is an antibiotic. It kills the bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.

• Bacterial infections

Ceftibuten inhibits bacterial cell wall synthesis. It is stable to hydrolysis by many beta-lactamases and has greater activity than 1st or 2nd generation cephalosporins against gm-ve bacteria. It is less active in vitro than cefexime against S. pneumoniae.

Adult Dose: Oral Respiratory tract infections, Urinary tract infections Adult: 400 mg once daily for 10 days. Child Dose: Child: 12 years old or >45 kg: As in adults Renal Dose: Renal impairment: CrCl (ml/min) 30-49 200 mg once daily. 5-29 100 mg once daily.

Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Ceftibuten may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Ceftibuten, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Allergic reaction • Stomach pain • Diarrhea

[SAFE] Ceftibuten does not usually affect your ability to drive. Your doctor has prescribed Ceftibuten to cure your infection and improve your symptoms. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection harder to treat. Discontinue Ceftibuten and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing. Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools. Take it with food to avoid an upset stomach. Avoid consuming alcohol while taking Ceftibuten as it may cause increased side effects.

Hypersensitivity to cephalosporins.

Enhanced nephrotoxicity of aminoglycosides. Increased serum concentration w/ probenecid. Decreased serum concentration w/ zinc salts.

[SAFE] Consuming alcohol with Ceftibuten does not cause any harmful side effects.

[SAFE IF PRESCRIBED] Ceftibuten is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

[CAUTION] Ceftibuten should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.

[CAUTION] Ceftibuten should be used with caution in patients with kidney disease. Dose adjustment of Ceftibuten may be needed. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Ceftibuten in patients with liver disease. Please consult your doctor.

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