৳ 11.60/unit
Pack: ৳ 116
৳ 11.60/unit
Pack: ৳ 116
At a glance
Lynestrenol is a synthetic progestagen used for polymenorrhoea, menorrhagia, metrorrhagia, amenorrhoea, oligomenorrhoea, premenstrual syndrome, endometriosis, endometrial carcinoma, and benign breast disease.
Indications
- Polymenorrhoea
- Menorrhagia and metrorrhagia
- Primary and secondary amenorrhoea and oligomenorrhoea (selected cases)
- Premenstrual syndrome
- Endometriosis
- Endometrial carcinoma (selected cases)
- Benign breast disease
- Suppression of menstruation, ovulation, and dysmenorrhoea
- Postponement of menstruation
- Adjunct to estrogen therapy in pre- and postmenopause
Pharmacology
Lynestrenol is converted to active norethisterone after oral administration, which exhibits progestational effects. It influences the endometrium like progesterone and suppresses ovulation with continuous use.
Dosage
Polymenorrhoea: 1 tablet daily on days 14-25 of the cycle
Premenstrual syndrome: 1 tablet daily on days 4-25 of the cycle
Endometriosis: 1-2 tablets daily for at least 6 months
Endometrial carcinoma: 6-10 tablets daily for prolonged periods
Benign breast disease: 1 tablet daily on days 14-25 of the cycle for at least 3-4 months
Menorrhagia/Metrorrhagia: 1 tablet daily on days 14-25 of the cycle (repeat for next 3 cycles)
Side effects
Common Side Effects (>10%):
- Breakthrough bleeding or spotting (first 2 months)
- Change in libido
- Nausea or gastrointestinal disturbances
- Weight increase
Occasional (1-10%) or Rare (<1%):
- Headache, migraine, dizziness, nervousness, depression
- Increased sweating, acne, hirsutism, chloasma, rash, pruritus
- Jaundice, liver function changes, lipoprotein profile changes
- Reduced glucose tolerance, breast pain, edema
Use in pregnancy
Use in Pregnancy: Lynestrenol is contraindicated during pregnancy.
Precautions & warnings
- Avoid sun exposure if tendency to chloasma
- Monitor liver function, carbohydrate metabolism, and hemostasis
- Periodic medical examinations during prolonged treatment
- Close supervision in patients with circulatory disorders or severe depression
Overdose effects
No specific overdose information available; symptomatic and supportive measures should be employed.
Storage conditions
Store in a cool and dry place, away from light; keep out of reach of children.