Oxaliplatin PhaRes50mg/Vial

Oxaliplatin is used in the treatment of cancer of colon and rectum. It shows its working by stopping or slowing down the growth of cancer cells. Oxaliplatin is given as an injection into vein by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Nausea, fatigue, vomiting, and diarrhea are some common side effects of this medicine. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. It may cause some serious allergic reaction, inform your doctor if you notice sore lips or mouth ulcers, rash, itching and difficulty breathing. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels. Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. It makes men infertile, hence men should take doctor advice about the freezing of sperm before the treatment. You must avoid driving after taking this medicine as it may cause dizziness. Oxaliplatin is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells which stops their growth and multiplication.

• Cancer of colon and rectum

Oxaliplatin, a platinum-containing complex similar to cisplatin, is an alkylating agent. After intracellular hydrolysis, the platinum compound binds to DNA forming cross-links which inhibit DNA replication and transcription, resulting in cell death.

Adult Dose: Intravenous Advanced colorectal cancer Adult: Day 1: Oxaliplatin 85 mg/m² IV + leucovorin 200 mg/m² IV infused over 2 hr, THEN 5-FU 400 mg/m² IV bolus over 2-4 minutes, THEN 5-FU 600 mg/m² IV infusion in D5W (500 mL) over 22 hr Day 2: Same regimen WITHOUT oxaliplatin Repeat every 2 weeks Adjuvant therapy in stage III colon cancer Adult: Day 1: Oxaliplatin 85 mg/m² IV + leucovorin 200 mg/m² IV infused over 2 hr, THEN 5-FU 400 mg/m² IV bolus over 2-4 minutes, THEN 5-FU 600 mg/m² IV infusion in D5W (500 mL) over 22 hr Day 2: Same regimen WITHOUT oxaliplatin Every 2 wk; given for 12 cycles, for a total of 6 months Dose Modification If persistent Grade 2 neuropathy, decrease dose to 75 mg/m² If persistent Grade 3 neuropathy, consider discontinuing oxaliplatin After recovery from grade 3/4 GI or grade 3/4 hematological toxicity: Decrease dose to 75 mg/m² , AND decrease 5-FU by 20% (300 mg/m² bolus, 500 mg/m² infusion) Child Dose: Safety and efficacy not established Renal Dose: Renal Impairment Exposure of unbound platinum tends to increase in renally impaired patients Mild (CrCl 50-80 mL/min): No dosage adjustment required Moderate (CrCl 30-49 mL/min): No dosage adjustment required Severe (CrCl <30 mL/min): Reduce starting dose

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Oxaliplatin, please consult your doctor.

Common: • Nausea • Fatigue • Anemia (low number of red blood cells) • Vomiting • Diarrhea • Decreased white blood cell count (neutrophils) • Low blood platelets • Increased liver enzymes • Peripheral neuropathy (tingling and numbness of feet and hand) • Stomatitis (Inflammation of the mouth)

[UNSAFE] Oxaliplatin may cause side effects which could affect your ability to drive. Oxaliplatin_name$ treatment may result in an increased risk of dizziness, nausea, and vomiting, and other neurological symptoms that affect walking and this may affect your ability to drive. Oxaliplatin is given as an injection into veins under the supervision of a doctor.

Pregnancy. Peripheral neuropathy with functional impairment. Severe renal impairment.

May decrease plasma levels of digoxin. May increase risk of toxicity with nephrotoxic drugs. When administered as sequential infusions, taxane derivatives (docetaxel, paclitaxel) should be administered before oxaliplatin to limit myelosuppression and enhance efficacy.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Oxaliplatin. Please consult your doctor.

[CONSULT YOUR DOCTOR] Oxaliplatin is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[UNSAFE] Oxaliplatin is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

[CAUTION] Oxaliplatin should be used with caution in patients with severe kidney disease. Dose adjustment of Oxaliplatin may be needed. Please consult your doctor. Limited information is available on the use of Oxaliplatin in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease. [CAUTION] Oxaliplatin should be used with caution in patients with liver disease. Dose adjustment of Oxaliplatin may be needed. Please consult your doctor.

Is ulcers curable G2 stage of cancer in rectum area Needs evaluation Please meet a Gastro surgeon My dad is suffering from colon cancer How to get rid of it Surgery is main stay of treatment, which should be followed by chemotherapy. Colon cancer What treat many I have to give Complete reports along with the patient is need to be seen before starting the treatment I hv phobia of cancer plzzzzzz I m suffering from mild stomach pain change in bowel movement and lack of apputite and i m depressed to thik about that it s a some type of cancer like stonach cancer or colon cancer All day i think about cancer in my body You need psychological counseling Diagnosed with colon cancer 30 by 40 mm. There is also lump near liver, how ever it could not be verified whether it is benign or malign. Please suggest the way to diagnose the tumour near liver and also the treatment and cost to cure colon cancer Do only pet scan , it will guide.Needs chemotherapy followed by surgery What are the home remedies on Colone cancer? no as such home remedy to treat colon cancer, case has to be first seen, before prescribing medicine. Giloy ras. wheat grass juice, aamal ras, neem ras, cow urine , each 20 ml twice is helpful