oshudhkosh

Oxat 20

Rx
Dosage form:
Tablet
Pack size:
Strip (10 Tablet)

৳ 12.03/unit

Pack: ৳ 120.30

At a glance

Paroxetine Hydrochloride — brands, prices, indication, dosage and side effects available in Bangladesh.

Description

Paroxetine Hydrochloride is a type of antidepressant belonging to the selective serotonin reuptake inhibitor (SSRI) group of medicines. It is widely prescribed to treat depression and anxiety-related conditions like panic disorder, obsessive-compulsive disorder, and post traumatic stress disorder (PTSD). Paroxetine Hydrochloride helps many people to recover from depression by improving their mood and relieving anxiety and tension. It can be taken with or without food. The dose and how often you need it will be decided by your doctor so that you get the right amount to control your symptoms. Your doctor may start you on a lower dose and increase it gradually. Do not change the dose or stop taking it without talking to your doctor, even if you feel well. Doing so may make your condition worse or you may suffer from unpleasant withdrawal symptoms (anxiety, restlessness, palpitations, dizziness, sleep disturbances, etc). To get the most benefit, take this medicine regularly at the same time each day. Your doctor may advise you to take it in the morning if you have trouble sleeping. It may take a few weeks before you start feeling better. Let your doctor know if you do not see any improvement even after 4 weeks. Some common side effects of Paroxetine Hydrochloride include nausea, fatigue, dry mouth, loss of appetite, increased sweating, dizziness, nervousness, tremors, insomnia (difficulty in sleeping), and constipation. Sexual side effects like decreased sexual drive, delayed ejaculation, and erectile dysfunction may also be seen. Let your doctor know straight away if you develop any sudden worsening of mood or any thoughts about harming yourself. Before taking this medicine, you should tell your doctor if you have epilepsy (seizure disorder or fits), diabetes, liver or kidney disease, heart problems, or glaucoma. These may affect your treatment. Pregnant or breastfeeding women should also consult their doctor before taking it. Some other medicines may affect the way it works, especially other antidepressants and medicines called MAO inhibitors. Please tell your doctor about all the medicines you are taking to make sure you are safe. Paroxetine Hydrochloride is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It works by increasing the levels of serotonin, a chemical messenger in the brain. This improves mood and physical symptoms of depression and also relieves symptoms of post traumatic stress disorder, panic disorder, anxiety and obsessive-compulsive disorder.

Indications

• Depression • Obsessive-compulsive disorder • Post traumatic stress disorder • Panic disorder • Anxiety

Mechanism of action

Paroxetine selectively inhibits the reuptake of serotonin. It has limited direct action at other neurotransmitter sites including muscarinic receptors.

Dosage

Adult Dose: Oral Depression, Anxiety, Posttraumatic stress disorder Adult: 20 mg daily, increase gradually, if necessary, by 10-mg increments wkly; max: 50 mg/day. Obsessive compulsive disorder, Social anxiety disorder Adult: Initially, 20 mg daily, increase wkly in 10-mg increments. Maintenance: 40-60 mg daily. Panic disorder with or without agoraphobia Adult: Initially, 10 mg daily, increase wkly in 10-mg increments according to clinical response. Maintenance: 40-60 mg daily. Elderly: Initially, 10 mg daily, increase if needed by 10 mg/day at 1 wk intervals; max: 40 mg daily. Hepatic impairment: Severe: 10 mg daily, increase to a max of 40 mg daily as necessary. Child Dose: Safety and efficacy not established Renal Dose: Renal impairment: Severe: 10 mg daily, increase to a max of 40 mg daily as necessary.

Administration

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Paroxetine Hydrochloride may be taken with or without food, but it is better to take it at a fixed time.

Side effects

Common: • Delayed ejaculation • Low sexual desire • Nausea • Tremor • Confusion • Dizziness • Dryness in mouth • Erectile dysfunction • Fatigue • Increased sweating • Insomnia (difficulty in sleeping) • Loss of appetite • Nervousness • Sleepiness

Precautions & warnings

[UNSAFE] Paroxetine Hydrochloride may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. It can take 2-3 weeks for Pexep CR 12.5 Tablet to start working. Do not stop treatment suddenly as this may cause upset stomach, flu-like withdrawal symptoms and sleep disturbance. If your doctor asks you to stop Pexep CR 12.5 Tablet, you should reduce the dose slowly over 4 weeks. Avoid consuming alcohol when taking Pexep CR 12.5 Tablet, as it may cause excessive drowsiness and calmness. The addiction/dependence potential of Pexep CR 12.5 Tablet is very less.

Contraindications

Use with or within 14 days of MAOIs; concurrent use with thioridazine or pimozide.

Drug interactions

Levels/effects inhibited by cyproheptadine, phenytoin. Levels/effects increased by carbamazepine, cimetidine, CYP2D6 inhibitors (e.g. chlorpromazine, delavirdine, fluoxetine, miconazole, pergolide, quinidine, quinine, ritonavir, ropinirole). Increases levels/effects of atomoxetine, carvedilol, clozapine, CYP2B6 substrates (e.g. bupropion, promethazine, propofol, selegiline, sertraline), CYP2D6 substrates (e.g. amphetamines, selected beta-blockers, dextromethorphan, fluoxetine, lidocaine, mirtazapine, nefazodone, risperidone, ritonavir, thioridazine, TCAs, venlafaxine), duloxetine, galantamine, mexilitine, pimozide, procyclidine, propafenone. Decreases levels/effects of CYP2D6 prodrug substrates (e.g. codeine, hydrocodone, oxycodone, tramadol). Inhibits the metabolism of dextromethorphan, haloperidol, thioridazine. Enhances bradycardic effect of beta-blockers. Enhances toxic effects of other CNS depressants. Increased risk of serotonin syndrome with amphetamines, SSRIs, meperidine, nefazodone, trazodone, serotonin agonists, sibutramine, sympathomimetics, tramadol, venlafaxine. Increases risk of bleeding with NSAIDs, aspirin, warfarin, or other drugs affecting coagulation. Increases sensitivity to amphetamines. Neurotoxicity with lithium. Additive hyponatraemia with loop diuretics. Mania or hypertension with selegiline. Potentially Fatal: Fatal reactions with nonselective MAOI.

Food interactions

[UNSAFE] It is unsafe to consume alcohol with Paroxetine Hydrochloride.

Use in pregnancy

[UNSAFE] Paroxetine Hydrochloride is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Use in lactation

[CONSULT YOUR DOCTOR] Paroxetine Hydrochloride is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Renal / hepatic impairment

[CAUTION] Paroxetine Hydrochloride should be used with caution in patients with kidney disease. Dose adjustment of Paroxetine Hydrochloride may be needed. Please consult your doctor. [CAUTION] Paroxetine Hydrochloride should be used with caution in patients with liver disease. Dose adjustment of Paroxetine Hydrochloride may be needed. Please consult your doctor.

Common questions

What is the best ayurvedic medicine for lethargy,dullness,obsessive compulsive disorder, bipolar mood disorder,general anxiety disorder,gas,bloating,low digestive strength,low body energy,low concentration,too much attachment and paranoid behavior? https://www.1mgayush.com/otc/jiva-ashwagandha-tablet-otc3299671-1 Tablet after lunch & dinner, Take at least 1-2 months. I have Obsessive compulsive Disorder. Prescribe the medication. Hi Kindly share your symptoms of your Problem how to tackle depression and post traumal stress disorder? Psychiatric evaluation is based on history, clinical symptoms, personality factors, ongoing psychosocial stressors and frequency and severity of symptoms. It requires direct interaction with the patient on a regular basis. Once diagnosed, a management plan is formed based on intensity and frequency of symptoms and associated biological and psycho social factors. A complete solution to ones problems in a single question is thus not possible. Internet will give you generalised tips and tricks but they are hardly of any use. I suggest you to visit a psychiatrist in your vicinity for clinical evaluation. Sir i am suffering from Anxiety, IBS and Obsessive compulsive disorder I want to how i get Ayurveda medicine You should contact Ayurvedic doctor in person before starting the treatment PANIC ATTACK ANXIETY DISORDER T Anxiety is the result of a hyperarousal state of nervous system due to a low threshold for threat perception. In simpler words, it's an ongoing flight or fight response. It can elicit a neuro-hormonal response understood as Flight or Fright reaction kicking in physiological cascade of symptoms ranging from palpitations, tachycardia, breathlessness, increased bowel movement, increase frequency of urination, dizziness, muscle tension or pain, trembling, dizziness, blurring of vision to restlessness, confusion and fainting spells. Chronic stress causes prolonged anxiety response with the consequences of slowed me ration, lack of concentration, headaches, fluctuations in blood pressure and increased wear and tear of body tissues. Identifying your stressors, learning to deal with them, de stressing regularly by doing something that makes one feel good, yoga and meditation are some non pharmacological strategies to deal with it. If the condition is persisting for a long time, it's better to see a psychiatrist. Mental Depression , Anxiety disorder Depression is a persistent state of sadness that is the result of interaction between one's inner biological and psychological state and gets triggered of with environmental stressors. Reactive depression is in response to a situation like loss, sickness, trauma etc. Endogenous depression occurs without any noticeable environmental stressors. Psychological symptoms include lack of interest, negative thinking, irritability, frustration, feeling demotivated etc. Somatic symptoms like fatigue/ weakness/ lack of sleep/ lack of appetite and other physical symptoms are common. Anxiety is common. In severe cases one may feel helpless and hopeless enough to wish for death or attempt suicide. Treatment includes physical and psychiatric work up following which medicines can be prescribed. In milder cases, psychotherapy or counselling is recommended. panic disorder, hypochondria syndrome & anxiety neurosis Continue medicines as prescribed and follow up with your psychiatrist

⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.