৳ 120.45/unit
Pack: ৳ 120.45
৳ 120.45/unit
Pack: ৳ 120.45
At a glance
Cephradine is a first generation cephalosporin antibiotic used to treat pneumonia, pharyngitis, otitis media, skin infections, respiratory tract and urinary tract infections.
Indications
- Upper Respiratory Tract Infections (sinusitis, pharyngitis, tonsillitis, otitis media)
- Lower Respiratory Tract Infections (bronchitis, lobar pneumonia)
- Urinary Tract Infections (cystitis, urethritis, pyelonephritis)
- Skin and Soft Tissue Infections (abscess, cellulitis, furunculosis, impetigo)
- Surgical Prophylaxis
- Genitourinary Tract Infections
- Acute Prostatitis
Pharmacology
Cephradine is a semisynthetic broad spectrum bactericidal antibiotic, it is active against infections caused by both gram-positive and gram-negative microorganisms. Both penicillinase producing and nonproducing staphylococci are sensitive to Cephradine. The main site of action of Cephradine is the cell wall of bacteria. Cell wall of sensitive organism contains peptidoglycan. Cephradine inhibits cross-linking process and as a result cell wall with many pores are formed, thus lysis of bacteria occur due to external osmotic pressure.
Dosage
Adult Dose (Oral):
| Infection Type | Dose | Schedule |
|---|---|---|
| Susceptible infections | 1-2 g/day | 2-4 divided doses (Max 4 g/day) |
| Skin, Respiratory tract infections | 250 mg or 500 mg | Every 6 hours or every 12 hours |
| Lobar pneumonia | 500 mg or 1 g | Every 6 hours or every 12 hours |
| Urinary tract infections | 500 mg | Every 12 hours |
| GI tract infections | 500 mg | 3-4 times daily |
Adult Dose (Parenteral): Severe infections 2-4 g/day (4 divided doses), Max 8 g/day.
Surgical Prophylaxis: 1-2 g pre-op (IM/IV).
Pediatric Dose (Oral): 25-50 mg/kg/day (2-4 divided doses); Otitis media: 75-100 mg/kg/day (6-12 hourly).
Pediatric Dose (Injection): 50-100 mg/kg/day (4 divided doses); severe infections up to 200-300 mg/kg/day.
Renal Dose:
| Creatinine Clearance (ml/min) | Dose | Schedule |
|---|---|---|
| >20 | 500 mg | Every 6 hours |
| 5-20 | 250 mg | Every 6 hours |
| <5 | 250 mg | Every 12 hours |
Side effects
Common Side Effects:
- Diarrhea
- Nausea
- Vomiting
- Leukopenia
- Neutropenia
- Eosinophilia
- Rash
- Pruritus
- Joint pain
- Increased BUN and creatinine
- Dizziness
Rare: Glossitis, heartburn, chest tightness, abdominal pain, vaginitis, candida overgrowth, blood disorders, hepatic enzyme elevation, interstitial nephritis.
Potentially Fatal: Pseudomembranous colitis.
Use in pregnancy
Safety in pregnancy has not been established. Animal studies have not demonstrated teratogenicity. Should be used during pregnancy only if clearly needed. Pregnancy Category B.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Use with caution in renal impairment; dose adjustment needed.
- History of penicillin sensitivity; caution due to cross-sensitivity risk.
- Prolonged use may result in superinfection due to resistant organisms.
- Caution during pregnancy and lactation.
- Cephalosporins may cause false positive Coombs' test.
- May cause false positive urine glucose with Benedict's or Fehling's solutions or Clinitest tablets.
- Contains lactose; not recommended for patients with galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption.
Overdose effects
Overdose symptoms are generally nausea, vomiting, diarrhea and gastric upsets. Treatment is mainly supportive although gastric lavage will be necessary if a large amount has been ingested.
Storage conditions
Cephradine Suspension should be freshly prepared. Reconstituted suspension should be used within 7 days at room temperature or within 14 days if refrigerated. Injection solutions should be used within 2 hours at room temperature or within 12 hours at 5°C. Do not use later than the date of expiry. Keep out of reach of children.