Paloxi0.5mg
Rx- Generic:
- Palonosetron
- Company:
- Beacon Pharmaceuticals PLC
- Dosage form:
- Tablet
- Pack size:
- Strip (10 Tablet)
৳ 20.06/unit
Pack: ৳ 200.60
At a glance
Palonosetron — brands, prices, indication, dosage and side effects available in Bangladesh.
Description
Palonosetron is an antiemetic medicine commonly used to control nausea and vomiting due to certain medical conditions like stomach upset. It is also used to prevent nausea and vomiting caused due to any surgery, cancer drug therapy or radiotherapy. Palonosetron will not relieve other side effects associated with cancer treatments. It also has little effect on vomiting caused by motion sickness. You should take this medicine in the dose and duration advised by your doctor. But, it is better to take this medicine at a fixed time. Remember you should not stop taking the medication suddenly without talking to your doctor. In case you vomit within one hour of taking a dose then take another dose and avoid heavy meals throughout the day. The most common side effects of taking this medicine include headache and constipation. Dizziness and sleepiness may also occur, so do not drive or do anything that requires mental focus until you know how this medicine affects you. These symptoms should disappear when you stop taking the medicine. However, if these bother you or do not go away, consult your doctor who may be able to suggest ways of preventing or reducing them. Before taking this medicine, tell your doctor if you have heart or liver problems or a blockage in your stomach or intestines. Also, tell your doctor about any other medicine you are using, especially medicines to treat epilepsy, heart problems, cancer and depression. These may affect, or be affected by, this medicine. If you are pregnant or breastfeeding, ask for advice from your healthcare team. Palonosetron is an antiemetic medication. It works by blocking the action of a chemical messenger (serotonin) in the brain that may cause nausea and vomiting during anti-cancer treatment (chemotherapy) or after surgery.
Indications
• Nausea • Vomiting
Mechanism of action
Palonosetron is a selective 5-HT3 antagonist that is used in the prevention of acute and delayed emesis in emetogenic cancer chemotherapy regimens.
Dosage
Adult Dose: Prevention of Chemotherapy-induced Nausea & Vomiting Intravenous Adult: 0.25 mg IV as a single dose. To be given over 30 sec and 30 minutes before chemotherapy. Do not repeat within 7 days. Oral Alternatively 0.5 mg tablet/capsule approximately 1 hour before the start of chemotherapy. Then 0.5 mg tablet once daily. Prevention of Postoperative Nausea & Vomiting Adult: 0.075 mg IV as a single dose immediately before induction of anaesthesia. Hepatic impairment: Dose adjustment not necessary Child Dose: Prevention of Postoperative Nausea & Vomiting <18 years: Safety and efficacy not established Prevention of Chemotherapy-induced Nausea & Vomiting <1 month: Safety and efficacy not established 1 month to 17 years: 20 mcg/kg IV infused over 15 minutes x1, beginning 30 minutes before chemotherapy; not to exceed 1.5 mg/dose Renal Dose: Renal impairment: Dose adjustment not necessary
Administration
Take this medicine in the dose and duration as advised by your doctor. Do not handle the tablets with wet hands. Put it in your mouth but do not swallow it. Palonosetron may be taken with or without food, but it is better to take it at a fixed time.
Missed dose
If you miss a dose of Palonosetron, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Side effects
Common: • Headache • Constipation
Precautions & warnings
[UNSAFE] Palonosetron may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. You have been prescribed EME OD Tablet MD for prevention of nausea and vomiting caused after surgery or due to chemotherapy and radiotherapy. Unlike some other nausea medicines, the side effects for EME OD Tablet MD are relatively mild. It is fast-acting and starts working within 30 minutes. If you vomit within one hour of taking a dose, take another dose. Avoid heavy meals and try eating small nourishing snacks throughout the day. Also, sip water regularly to help avoid dehydration.
Contraindications
History of hypersensitivity.
Drug interactions
May have additive effect on prolonging QT with drugs e.g. moxifloxacin, erythromycin, antipsychotics and TCAs.
Food interactions
[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Palonosetron. Please consult your doctor.
Use in pregnancy
[SAFE IF PRESCRIBED] Palonosetron is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Use in lactation
[SAFE IF PRESCRIBED] Palonosetron is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Renal / hepatic impairment
[SAFE IF PRESCRIBED] Palonosetron is safe to use in patients with kidney disease. No dose adjustment of Palonosetron is recommended. [SAFE IF PRESCRIBED] Palonosetron is safe to use in patients with liver disease. No dose adjustment of Palonosetron is recommended.
Common questions
I am in the first month of pregnancy and I am experiencing nausea, vomiting, stomach pain (moderate to severe) as well as discomfort. Current medications is Susten SR 200 (OD), Duvadilan retard (OD), Doxinate (BD), Folverine D (OD), Fertigyn 500 (1 amp weekly) and aciloc 150 (BD). What should I do to ease my situation. Please suggest The med suggested are to support of pregnancy and for acidity and nausea and vomiting. Continue the same. You can upgrade the med for vomiting after consulting your Suggest treatment for pregnancy nausea vomiting, even after taking doxinate od Take Syp vomitab 10 ml twice before meal, of Charak company My wife is 13 week pregnent her docter change her tablet from mvista to doxynate plus me I know the reason is both tablet aee same. Docter asked to taje doxynate plus 2 tablet at bed time.please suggest. Doxynate is tablet to stop vomiting dear. It is ok to take them at bed time. It is widely recommended to take for nausea and vomiting of pregnancy. Dear Sir/madam Pls advise whats the utility difference in : (1) Ondem-8mg & Ondem-8mg-MD (2) Evion-400 & Evion-600 Ondem 8 mg/MD (sustained release) are the same, prescribed in different doses at different intervals, depending on the cause of nausea and vomiting.Evion is basically Vitamin E. 400 and 600 mg are two different doses, thats all. Sir suggest me some anti omitting medicine Tab ondem-MD 1Sos for vomiting I am 72 days pregnant. I can't able to eat anything. Always feeling vomiting. I am more worried about my baby. Will my baby get sufficient nutrition? Please start taking Doxinate tablet thrice a day to prevent nausea. As nausea decreases, you should be able to eat properly. What is side effect of primolut n Bloating, pain abdomen, nausea, vomiting etc are common side of Primolut. Vomiting and doses issue with metformin and other salt with istanet 500mg tablet! How to avoid vomiting and nausea ask your doctor to change your medicine