৳ 275/unit
Pack: ৳ 275
৳ 275/unit
Pack: ৳ 275
At a glance
Pancuronium Bromide is a non-depolarizing neuromuscular blocking agent used for skeletal muscle relaxation during surgery and to facilitate endotracheal intubation.
Indications
- Adjunct to general anesthesia
- Facilitating endotracheal intubation
- Skeletal muscle relaxation during medium and long duration surgical procedures
Pharmacology
Pancuronium competitively binds to nicotinic receptors at the neuromuscular junction to block acetylcholine action, preventing muscle contraction and causing skeletal muscle relaxation.
Dosage
Adult Dose (IV):
- Intubation/Initial: 0.04-0.1 mg/kg
- Maintenance: 0.015-0.1 mg/kg q30-60min OR 0.1 mg/kg/hr continuous infusion
- After suxamethonium: 0.02-0.06 mg/kg
- Dose based on ideal body weight
Pediatric Dose (IV):
- Neonates (0-30 days): 0.03-0.04 mg/kg (initial); 0.01-0.02 mg/kg (maintenance)
- >1 month: Same as adult
Side effects
Common Side Effects:
- Tachycardia
- Hypertension
- Bradycardia
- Bronchospasm
- Hypotension
- Pain or local skin reactions at injection site
- Excessive salivation
Use in pregnancy
Use in Pregnancy: Pancuronium may be unsafe during pregnancy (Category C); animal studies show adverse effects.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Caution in burn injury, biliary tract disease, pulmonary disease, muscular dystrophies, myasthenia gravis, electrolyte disturbance, dehydration, CV disease, edema, renal and hepatic impairment
- Obese patients: Dose based on ideal body weight
Overdose effects
Overdose: Prolonged apnea, respiratory depression and muscle weakness; reverse with neostigmine and atropine; respiratory support.
Storage conditions
Store in a cool and dry place, away from light; keep out of reach of children.