PDS1000 ml

PDS 1000 ml is a dialysis solution manufactured by OSL Pharma Limited in Bangladesh. Its active ingredient is Peritoneal Dialysis Solutions.

Indications

This is used for dialysis of peritoneum.

Contraindications

Patients with excessive obesity and in pregnancy.

Composition

• Each 100 ml of solution contains-
• Calcium Chloride 22 mg
• Potassium Chloride 22 mg
• Dextrose Anhydrous 1.5 gm
• Magnessium Chloride 15.2 mg
• Sodium Acetate 476 mg
• Sodium Chloride 556 mg

Pharmacology

Calcium chloride

is used to prevent or treat negative calcium balance. It also regulates action potential excitation threshold to facilitate nerve and muscle performance.

Potassium chloride

is a major cation of the intracellular fluid. It plays an active role in the conduction of nerve impulses in the heart, brain and skeletal muscle; contraction of cardiac skeletal and smooth muscles; maintenance of normal renal function, acid-base balance, carbohydrate metabolism and gastric secretion.

Sodium chloride

is the major extracellular cation. It is important in electrolyte and fluid balance, osmotic pressure control and water distribution as it restores sodium ions. It is used as a source of electrolytes and water for hydration, treatment of metabolic acidosis, priming solution in haemodialysis and treatment of hyperosmolar diabetes. It is also used as diluents for infusion of compatible drug additives.

Sodium lactate

is a sterile, nonpyrogenic solution that is used for fluid and electrolyte replenishment. It has metabolic alkalinising ability and is capable of inducing diuresis depending on the clinical condition of the patient.

Dextrose

is a monosaccharide that is used as a source of calories and water for hydration. It helps to reduce loss of body protein and nitrogen. It also promotes glycogen deposition in the liver. When used with insulin, it stimulates the uptake of potassium by cells, especially in muscle tissue, thus lowering serum potassium levels.

Dosage & Administration

In case of intermittent peritoneal dialysis (IPD): 2 liters solution is instill into the abdominal cavity over a period of 1 hour then drained from the cavity.

The exchange should be continued for 8-36 hours.

Interaction

There are no known drug interactions and none well documented.

Side Effects

During dialysis amino acids and water soluble vitamins may be lost. Fluid and electrolyte imbalance, hypovolemia, hypotension or muscle cramping may occur.

Pregnancy & Lactation

Category - Not Classified. FDA has not yet classified the drug into a specified pregnancy category

Precautions & Warnings

It is used for peritoneal dialysis purposes only.

Therapeutic Class

Peritoneal dialysis solution

Disclaimer: This information is for reference only. Always consult a registered physician before taking any medicine.