৳ 30.09/unit
Pack: ৳ 30.09
৳ 30.09/unit
Pack: ৳ 30.09
At a glance
Sildenafil is a PDE5 inhibitor used for erectile dysfunction and pulmonary arterial hypertension. It increases blood flow to the penis during sexual stimulation by raising cGMP levels in the corpus cavernosum.
Indications
- Erectile dysfunction (ED)
- Pulmonary arterial hypertension (PAH)
Pharmacology
Sildenafil inhibits PDE5 enzyme, preventing cGMP degradation in the corpus cavernosum. During sexual stimulation, NO release leads to increased cGMP levels, which relaxes smooth muscles and dilates penile arteries, increasing blood flow and causing erection.
Dosage
Adult Dose (Oral):
- ED: 50 mg 1 hour before sexual activity; 25-100 mg based on tolerability; max 100 mg/dose, once daily
- Elderly (>65): Start with 25 mg
- Hepatic/Renal impairment: Start with 25 mg
- PAH: 20 mg 3 times daily (4-6 hours apart)
Side effects
Common Side Effects:
- Flushing, headache
- Dizziness, blurred vision
- Muscle pain, stomach upset
- Rash, nasal congestion
Serious (Rare):
- Prolonged erection (>4 hours)
- Sudden hearing loss
- MI, stroke, cardiac arrhythmia
Use in pregnancy
Use in Pregnancy: Sildenafil is not indicated for women; no adequate data; consult your doctor.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Do not use with organic nitrates (severe hypotension)
- Caution in severe cardiovascular disease, MI/stroke within 6 months
- Caution in anatomical penile deformities or predisposition to priapism
- Caution in retinitis pigmentosa
- Caution with alpha-blockers (hypotension)
Overdose effects
Doses up to 800 mg showed increased adverse events; provide standard supportive measures; hemodialysis not effective.
Storage conditions
Store in a dry place, away from light and heat; keep out of reach of children.