৳ 4,000/unit
Pack: ৳ 4,000
৳ 4,000/unit
Pack: ৳ 4,000
At a glance
Pegylated Erythropoietin is an erythropoietin receptor activator used for the treatment of anemia associated with chronic kidney disease (CKD) in adult patients on dialysis and patients not on dialysis.
Indications
- Anemia associated with chronic kidney disease (dialysis patients)
- Anemia associated with chronic kidney disease (non-dialysis patients)
Pharmacology
Pegylated erythropoietin is an erythropoietin receptor activator that stimulates erythropoiesis in the bone marrow. It provides extended half-life and greater in vivo activity through amide bond conjugation.
Dosage
Adult Dose (SC/IV):
- Initial dose (CKD dialysis and non-dialysis): 0.6 mcg/kg once every two weeks
- Once hemoglobin stabilized: May be given once monthly (double the dose)
- Initiate when Hb <10 g/dL; reduce/interrupt if Hb approaches/exceeds 11 g/dL
- Rapid Hb rise (>1 g/dL in 2 weeks): Reduce dose by 25%
- Inadequate response (Hb increase <1 g/dL after 4 weeks): Increase dose by 25%
Side effects
Side Effects:
- Increased mortality, myocardial infarction, stroke, and thromboembolism
- Increased mortality and/or tumor progression in patients with cancer
- Hypertension
- Seizures
- Pure red cell aplasia
- Serious allergic reactions
Use in pregnancy
Use in Pregnancy: Pregnancy Category C; unknown if excreted in human milk; caution required.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Targeting Hb >11 g/dL increases rate of serious adverse cardiovascular reactions
- Caution in patients with coexistent cardiovascular disease, stroke, seizures, etc.
- Control hypertension prior to and during treatment
- Monitor for changes in seizure frequency or premonitory symptoms
- If severe anemia and low reticulocyte count develop, withhold and evaluate for neutralizing antibodies
Overdose effects
Overdose can elevate hemoglobin levels above desired level; managed with discontinuation/reduction of dosage and/or phlebotomy. Severe hypertension has been observed.
Storage conditions
Store at 2-8°C in the refrigerator; protect from light; do not shake syringe; keep out of reach of children.