৳ 9.21/unit
Pack: ৳ 9.21
৳ 9.21/unit
Pack: ৳ 9.21
At a glance
Benzyl Penicillin is a penicillin-type antibiotic used to treat a variety of bacterial infections. It is effective in infections of the throat, ear, nasal sinuses, respiratory tract, skin and soft tissue, and sexually transmitted diseases like Syphilis.
Indications
- Meningitis
- Anthrax
- Community-acquired pneumonia
- Bacterial endocarditis
- Septicemia
- Diphtheria
- Syphilis
- Cellulitis
- Gonorrhea
- Aspiration pneumonia
- Lung abscess
- Septic arthritis
- Gangrene
- Prevention of rheumatic fever
Pharmacology
Benzylpenicillin has a bactericidal action against gram-positive bacteria, gram-negative cocci, some other gram-negative bacteria, spirochetes and actinomycetes. It inhibits final cross-linking stage of peptidoglycan production through binding and inactivation of transpeptidases on the inner surface of the bacterial cell membrane thus inhibiting bacterial cell wall synthesis. It is inhibited by penicillinase and other beta-lactamases.
Dosage
Adult:
- Bacterial endocarditis (with aminoglycoside): 1.2 g IV every 4 hours
- Group B streptococcal infection prophylaxis (intrapartum): Initial 3 g, then 1.5 g every 4 hours until delivery
- Meningococcal/Pneumococcal meningitis: 2.4 g every 4 hours (up to 18 g/day for meningococcal meningitis)
- Susceptible infections (IV/IM): 0.6-4.8 g/day in divided doses
Pediatric (Infants & Children):
- Bacterial infection (IV/IM): 100,000–250,000 units/kg/day every 4-6 hours
- Maximum daily dose: 24 million units
Renal Dose: Dosing interval should be no more frequent than every 8-10 hours.
Side effects
- Rash
- Vomiting
- Allergic reaction
- Nausea
- Diarrhea
- Urticaria
- Fever
- Joint pain
- Angioedema
- Serum sickness
- Hemolytic anemia
- Interstitial nephritis
- Neutropenia
- Thrombocytopenia
- CNS toxicity (including seizures)
- Anaphylaxis (potentially fatal)
Use in pregnancy
[SAFE IF PRESCRIBED] Benzyl Penicillin is generally considered safe to use during pregnancy (Pregnancy Category B). Animal studies have shown low or no adverse effects to the developing baby. Use under medical supervision.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Inform your doctor if allergic to penicillin or penicillin-type medicines
- Complete the full course - do not stop even if you feel better
- Stop and inform your doctor immediately if you develop allergic reactions (rash, swelling of face/throat/tongue, breathing difficulties)
- Dose adjustment needed in renal impairment (risk of neurotoxicity)
- Monitor serum potassium, renal and hematological status
- Avoid high doses in renal impairment or heart failure
- Avoid intrathecal route
Overdose effects
Overdose may cause neurotoxicity (seizures), especially in renal impairment. Consult a doctor if symptoms occur.
Storage conditions
Store below 25°C, away from light and moisture. Keep out of reach of children.