Pentasa 1gm

Mesalazine [5-aminosalicylic acid] __FORM__is a anti-inflammatory agents used to treat inflammatory bowel disease and some forms of arthritis. Mesalazine [5-aminosalicylic acid] __FORM__work by inhibiting the production of cyclo-oxygenase and prostaglandin, thromboxane synthetase, platelet activating factor synthetase, and interleukin-1 by macrophages so reduces the acute inflammatory response in inflammatory bowel disease. Mesalazine [5-aminosalicylic acid] __FORM__ works by diminishes infammation by blocking cyclooxygenase and inhibiting prostaglandin production in the colon.

Mesalazine [5-aminosalicylic acid] __FORM__use as a treatment of inflammatory bowel disease (IBD) ,including ulcerative colitis and Crohn's disease.

মেসালামাইনের ক্রিয়াকলাপের পদ্ধতি অজানা, তবে সিস্টেমিকের পরিবর্তে সাময়িক বলে মনে হয়। অ্যারাকিডোনিক অ্যাসিড মেটাবোলাইটের মিউকোসাল উৎপাদন, উভয় সাইক্লোক্সিজেনেস পাথওয়ের মাধ্যমে, অর্থাৎ, প্রোস্টানয়েডস এবং লিপক্সিজেনেস পাথওয়ের মাধ্যমে, অর্থাৎ লিউকোট্রিনস এবং হাইড্রোক্সিকোসেটেট্রেনোইক অ্যাসিডের মাধ্যমে, দীর্ঘস্থায়ী প্রদাহজনক অন্ত্রের রোগে আক্রান্ত রোগীদের মধ্যে বৃদ্ধি পায়। মেসালামাইন সাইক্লোক্সিজেনেসকে ব্লক করে এবং কোলনে প্রোস্টাগ্ল্যান্ডিন উৎপাদনে বাধা দিয়ে প্রদাহ কমায়।

It appears to work by blocking the production of inflammatory chemicals in the intestines. This helps to reduce inflammation and improve symptoms of IBD, including ulcerative colitis and Crohn's disease..

Adult Dose: Ulcerative colitis- Adults: Active disease: Individual dosage, up to 4 gm once daily or divided into 2-4 doses. Maintenance treatment: Individual dosage. Recommended dosage, 2 gm once daily. Geriatrics: Patients who are 65 years or older, caution should be taken to closely monitor blood cell counts during Mesalamine therapy. Child Dose: Pediatrics: The safety and efficacy in children below 6 years of age have not been established. There is only limited documentation for an effect in children (age 6-18 years). Children 6 years of age and older: Active disease: To be determined individually, starting with 30-50 mg/kg/day in divided doses. Maximum dose: 75 mg/kg/day in divided doses. The total dose should not exceed 4 g/day (maximum adult dose). Maintenance treatment: To be determined individually, starting with 15-30 mg/kg/day in divided doses. The total dose should not exceed 2 g/day (recommended adult dose). It is generally recommended that half the adult dose may be given to children up to a body weight of 40 kg; and the normal adult dose to those above 40 kg. Renal Dose: Elderly patients are more likely to have decreased renal function, 5-aminosalicylic acid ( mesalazine) should be used with care.

Mesalazine [5-aminosalicylic acid] __FORM__ is usually take will depend on the severity of pataient condition and individual needs. It is important to take the medication exactly as prescribed by your doctor.Do not crush, chew, or break the tablet.Mesalazine [5-aminosalicylic acid] __FORM__ may be taken on an empty or full stomach. However, taking it with to reduce the risk of stomach upset.

Take Mesalazine [5-aminosalicylic acid] __FORM__as soon as you remember .If it is almost time for your next dose, skip the missed dose and take next dose at the regular time. Do not take two doses at the same time.

• Stomach upset • Nausea • Diarrhea • Headaches • Vomiting • Abdominal pain • Skin rash

[SAFE] Mesalazine [5-aminosalicylic acid] __FORM__is generally considered safe to take while driving. If there is any problem during driving, stop taking it.

Not recommended for patients who have a known hypersensitivity to salicylates or to any other component of the formulation.

Concurrent use of other known nephrotoxic agents such as NSAIDs and Azathioprine may increase the risk of renal reaction

[UNSAFE] Taking Mesalazine [5-aminosalicylic acid] __FORM__ with alcohol can increase the risk of stomach upset and bleeding. Avoid alcohol while taking Mesalazine [5-aminosalicylic acid] __FORM__

[CONSULT YOUR DOCTOR] Mesalazine [5-aminosalicylic acid] __FORM__ has been shown to cross the placenta and may cause harm to the fetus. It should be given in pregnancy only if the potential benefit justifes the potential risk to the fetus.

[CAUTION] Mesalazine [5-aminosalicylic acid] __FORM__has been shown to pass into breast milk that’s why should take caution to take it. Caution is advised when it is administered to a nursing mother.

[CAUTION] Mesalazine [5-aminosalicylic acid] __FORM__ should be used with caution in patients who have known renal dysfunction or have a history of renal disease. [CAUTION] Patients with liver disease should use Mesalazine [5-aminosalicylic acid] __FORM__ with caution. The liver helps to break down Mesalazine [5-aminosalicylic acid] __FORM__ and people with liver disease may have higher levels of 5-aminosalicylic acid (mesalazine) in their blood. This can increase the risk of side effects.

Store below 30°C . Protect from light and moisture. Keep all medicines out of the reach of children.