osudhkosh
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Company•Square Pharmaceuticals PLC.

Peranel 4

Rx
Generic: Perampanel

৳ 25/unit

Pack: ৳ 250

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At a glance

Perampanel is an anti-epileptic drug used for the treatment of partial-onset seizures with or without secondarily generalized seizures in patients from 4 years of age and older, and as adjunctive therapy for primary generalized tonic-clonic seizures in patients from 12 years of age and older.

Indications
  • Partial-onset seizures with or without secondarily generalized seizures in patients from 4 years of age and older
  • Adjunctive therapy for primary generalized tonic-clonic seizures in patients from 12 years of age and older
Pharmacology

Perampanel is a non-competitive antagonist of the AMPA glutamate receptor on post-synaptic neurons. Glutamate is the primary excitatory neurotransmitter in the CNS. Perampanel reduces neuronal over-excitation by inhibiting AMPA receptors, helping to control seizures.

Dosage

Adult Dose (Oral):

  • Starting dose: 2 mg once daily at bedtime
  • May increase by increments of 2 mg weekly based on clinical response and tolerability
  • Maintenance dose for partial-onset seizures: 8-12 mg once daily at bedtime
  • Maintenance dose for primary generalized tonic-clonic seizures: 8 mg once daily at bedtime
  • Mild hepatic impairment: Max 6 mg/day; Moderate: 4 mg/day
  • Severe hepatic or renal impairment: Not recommended
  • Elderly: Increase dose no more frequently than every 2 weeks
Side effects

Side Effects:

  • Serious psychiatric and behavioral reactions
  • Suicidal behavior and ideation
  • Dizziness
  • Somnolence
  • Fatigue
  • Irritability
  • Falls
  • Nausea
  • Ataxia
  • Balance disorder
Use in pregnancy

Use in Pregnancy: Based on animal data, may cause fetal harm; no data on presence in human milk.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Monitor for suicidal thoughts or behavior
  • Monitor for dizziness, gait disturbance, somnolence, and fatigue
  • Monitor for falls and injuries
  • DRESS/Multi-organ hypersensitivity: Discontinue if no alternate etiology
  • Withdrawal of antiepileptic drugs may increase seizure frequency
Overdose effects

No overdose information available; consult your doctor if taken in excess.

Storage conditions

Protect from light and moisture; store below 30°C; keep out of reach of children.

Perampanel — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.