oshudhkosh

Pinor25mg

Rx
Dosage form:
Tablet
Pack size:
Tablet

৳ 4/unit

Pack: ৳ 4

At a glance

Imipramine Hydrochloride — brands, prices, indication, dosage and side effects available in Bangladesh.

Description

Imipramine Hydrochloride is known as a tricyclic antidepressant. It is used to treat depression and bedwetting in children of age 6 years and above. It is also effective in treating depression that is unresponsive to other treatments. Imipramine Hydrochloride works by increasing the levels of chemical messengers in the brain that stabilizes and enhances the mood. It is better to take it before bedtime because it can make you feel drowsy. It can be taken with or without food, but you should take it at a fixed time each day for better efficacy. The dose and duration will be decided by your doctor so that you get the right amount to control your symptoms. If you have missed any dose, take it as soon as you remember it. Do not skip any dose and finish the full course of treatment even if you feel better. This medication must not be stopped suddenly without talking to the doctor. Your dose may be modified or gradually decreased before stopping the medication. The most common side effects of this medicine include increased heart rate, blurred vision, dryness in the mouth, difficulty in urination and constipation. Initially, this medicine may also cause a sudden drop in blood pressure, especially when you change positions. It may even cause dizziness and sleepiness, do not drive or do anything that requires mental focus until you know how this medicine affects you. To lower the chances of dizziness, rise slowly if you have been sitting or lying down. It may also lead to weight gain in some people. Most of the common side effects tend to be mild and temporary. Your doctor may be able to suggest ways of preventing or reducing side effects if they bother you or do not go away. Serious side effects associated with this medicine are rare. Before taking this medicine, it is important to tell your doctor if you are taking or have recently taken any other medicines for the same or any other diseases. Pregnant and breastfeeding women should take this medicine with proper consultation and caution. This medicine is not known to be addictive, but you can experience additional side effects (withdrawal symptoms) if you stop taking it suddenly. If you notice any sudden mood change or get suicidal or self-harm thoughts, you must consult the doctor without delay. Also, remember to take this medicine as advised by the doctor as an overdose of this medication may lead to a serious health emergency. Consumption of alcohol should be avoided as alcohol interacts with this medicine to cause serious health issues. Imipramine Hydrochloride is a tricyclic antidepressant. It increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression.

Indications

• Depression • Bed-wetting

Mechanism of action

Imipramine is believed to increase the synaptic concentration of serotonin and/or norepinephrine in the CNS by inhibition of their reuptake by the presynaptic neuronal membrane. However, additional receptor effects have been found including desensitisation of adenyl cyclase, down regulation of β-adrenergic receptors, and down regulation of serotonin receptors.

Dosage

Adult Dose: Oral Depression Adult: Initially, 75 mg in divided doses, may gradually increase to 150-200 mg daily as necessary. Max: 300 mg/day. May give in divided doses or single dose HS Maintenance dose: 50-100 mg PO qDay Elderly: 10 mg daily, may gradually increase to 30-50 mg daily. Hepatic impairment: Severe: Contraindicated. Child Dose: Oral Nocturnal enuresis Child: 6-7 yr 20-25 kg: 25 mg; 8-11 yr 25-35 kg: 25-50 mg; >11yr 35-54 kg: 50-75 mg. Doses are given just before bedtime. Max treatment duration: 3 mth.

Administration

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Imipramine Hydrochloride may be taken with or without food, but it is better to take it at a fixed time.

Missed dose

If you miss a dose of Imipramine Hydrochloride, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Side effects

Common: • Increased heart rate • Blurred vision • Dryness in mouth • Difficulty in urination • Constipation • Orthostatic hypotension (sudden lowering of blood pressure on standing)

Precautions & warnings

[UNSAFE] Imipramine Hydrochloride may cause side effects which could affect your ability to drive. As Imipramine Hydrochloride may impair your alertness or cause drowsiness or blurred vision, and this may affect your ability to drive. Imipramine Hydrochloride is used for the treatment of depression and bedwetting in children. The main dose should be taken at night as this medicine may produce drowsiness or sleepiness. You may be asked for regular blood tests to monitor the blood cell count or level of sodium and sugar in the blood. Inform your doctor if you notice behavioral changes, mood changes and suicidal thoughts while taking this medicine. Do not drive or do anything that requires concentration until you know how this medicine affects you. Do not stop taking the medication suddenly without talking to your doctor.

Contraindications

Any degree of heart block or cardiac arrhythmias, recent MI, porphyria, narrow-angle glaucoma, urine retention, mania. Severe hepatic impairment. Childn <6 yr. Concomitant use w/ MAOIs.

Drug interactions

Increased plasma levels and effects with quinidine, cimetidine, SSRIs, propafenone, flecainide. Reduced plasma levels with barbiturates, phenytoin. May increase effects of anticholinergic drugs. Severe orthostatic hypotension with altretamine. Causes drowsiness and impaired performance in combination with alcohol. Potentially Fatal: Severe hypertension with adrenaline, noradrenaline and methylphenidate. Reduces hypotensive effects of guanethidine, bethanidine, debrisoquine, bretylium, methyldopa and clonidine. Possible serotonin syndrome with MAOIs, separate admin by 3 wk.

Food interactions

[UNSAFE] Imipramine Hydrochloride may cause excessive drowsiness with alcohol.

Use in pregnancy

[CONSULT YOUR DOCTOR] Imipramine Hydrochloride may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Use in lactation

[CONSULT YOUR DOCTOR] Imipramine Hydrochloride is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Renal / hepatic impairment

[CAUTION] Imipramine Hydrochloride should be used with caution in patients with kidney disease. Dose adjustment of Imipramine Hydrochloride may be needed. Please consult your doctor. [CAUTION] Imipramine Hydrochloride should be used with caution in patients with liver disease. Dose adjustment of Imipramine Hydrochloride may be needed. Please consult your doctor. Regular monitoring of liver function tests is recommended while you are taking this medicine.

Common questions

Bed wetting problem.i tried all the solution except medicines . Here I met local doctor who suggested me depsonil 25 for 2 months i start or not Hello, you can start this Medicine if recommended. But bet wetting needs psychological support from family members also. I am patient of depsonil dz tablet .But drug is not available in my state Bihar or nearest city Gorakhpur. Please help me where I found it , You need to consult psychiatrist and get alternate prescriptionOnce you get prescription, you can order medications on 1mg Bed wetting every night help pl Any medicine for bed wetting There are many underlying causes of your symptoms. Specific treatment can not be given unless we establish exact underlying cause. Please consult Pediatrician. will take detail history and will examine your child in detail. At time may ask you relevant investigations if necessary. All information will be used to determine exact underlying cause of problem. Depending upon cause will prescribe you treatment. I am suffering depression from 20 year I am consuming depsonil 25 mg and Trinicalm plus 10 mg but now days there is not good sleep is there any side effect on my health due to consuming medicine for long period All long term medicines need regular monitoring to identify if there are any side effects. The effects and sude effects have to be rationally balanced. Don&#x27;t continue medicines without follow up with the prescribing psychiatrist for proper monitoring. If you are having trouble sleeping, you may need a change of medication. Bed wetting i.e.urine at bed during night U need to see paediatrician near by Bed wetting in night since 1.5year My baby every night bed wetting pl explain. Reasons. Generally, bed-wetting before age 7 isn&#x27;t a concern. At this age, your child may still be developing nighttime bladder control. Most children outgrow bed-wetting on their own ? but some need a little help. In other cases, bed-wetting may be a sign of an underlying condition that needs medical attention. Consult your child&#x27;s doctor if: Your child still wets the bed after age 7 Your child starts to wet the bed after a few months or more of being dry at night Bed-wetting is accompanied by painful urination, unusual thirst, pink or red urine, hard stools, or snoring Children Bed Wetting Treatment Bed wetting Generally, bed-wetting before age 7 isn&#x27;t a concern. At this age, your child may still be developing nighttime bladder control. Most children outgrow bed-wetting on their own ? but some need a little help. In other cases, bed-wetting may be a sign of an underlying condition that needs medical attention. Consult your child&#x27;s doctor if: Your child still wets the bed after age 7 Your child starts to wet the bed after a few months or more of being dry at night Bed-wetting is accompanied by painful urination, unusual thirst, pink or red urine, hard stools, or snoring Bed wetting during sleep at night Generally, bed-wetting before age 7 isn&#x27;t a concern. At this age, your child may still be developing nighttime bladder control. Most children outgrow bed-wetting on their own ? but some need a little help. In other cases, bed-wetting may be a sign of an underlying condition that needs medical attention. Consult your child&#x27;s doctor if: ?Your child still wets the bed after age 7 ?Your child starts to wet the bed after a few months or more of being dry at night ?Bed-wetting is accompanied by painful urination, unusual thirst, pink or red urine, hard stools, or snoring

⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.