Pixorel 2.5

Apixaban is a medicine known as an anticoagulant or blood thinner. It helps prevent and treat blood clots. It is used to reduce the risk of stroke and heart attack. It prevents and treats clot formation in the veins of your legs, lungs, brain and heart. Apixaban is commonly used in patients with irregular heart rhythm (atrial fibrillation) to prevent clot formation. It also reduces the risk of getting clots in people who have undergone knee or hip replacement surgeries. It can be taken with or without food and it is best to take them at the same time each day. You may need to take this medicine for many years, even for life in some cases. Do not stop taking it or change the dose without guidance from your doctor. It could quickly put you more at risk of having a heart attack, stroke or thrombosis (formation of a blood clot within a blood vessel). You can reduce your risk of having a blood clot by making changes to your lifestyle, such as not smoking, eating a healthy diet, getting regular exercise and losing weight if you need to. The most common side effect of Apixaban is bleeding more easily than normal, for example, having nosebleeds or bruising. If you experience any symptoms, tell your doctor immediately. Other side effects include low blood pressure, nausea, and skin rash. Do not take this medicine if you have severe kidney or liver problems, if you are currently bleeding or if you are taking other medicines to reduce blood clotting. You should not breastfeed while using this medicine. Unlike other anticoagulants, a regular blood test (PT-INR) is not required while taking this medicine. Apixaban is a novel oral anticoagulant (NOAC). It works by preventing the formation of blood clots in the body.

• Deep vein thrombosis • Pulmonary embolism • Stroke prevention

Apixaban is an anticoagulant that inhibits platelet activation and fibrin clot formation via direct, selective and reversible inhibition of free and clot-bound factor Xa in both intrinsic and extrinsic coagulation pathways. Inhibition of coagulation factor Xa prevents conversion of thrombin and subsequent thrombus formation.

Adult Dose: Oral Adult Prevention of VTE: Elective hip or knee replacement surgery Tablet 2.5 mg twice daily. Initial dose should be taken 12-24 hr post-op. Recommended duration of treatment: Patient undergoing hip replacement surgery 32-38 days. Patient undergoing knee replacement surgery 10-14 days. Prevention of stroke and systemic embolism in non-valvular atrial fibrillation Adult: 5 mg bid. Decrease dose to 2.5 mg PO BID in patients with any 2 of the following characteristics: Age ?80 years Weight ?60 kg Serum creatinine ?1.5 mg/dL Oral Deep vein thrombosis, Pulmonary embolism Adult: 10 mg bid for 7 days, followed by 5 mg bid. Prevention of recurrence: 2.5 mg bid after at least 6 mth of treatment. Hepatic impairment Mild: No dosage adjustment required Moderate: Patients may have intrinsic coagulation abnormalities; data are limited and no recommendations are available Severe: Not recommended Renal Dose: Renal impairment, including with ESRD on dialysis Deep Vein Thrombosis: No dose adjustment recommended; clinical efficacy and safety studies did not enroll patients with ESRD on dialysis or patients with a CrCl <15 mL/min; dosing recommendations are based on pharmacokinetic and pharmacodynamic (anti-FXa activity) data in study subjects with ESRD maintained on dialysis Renal impairment (nonvalvular atrial fibrillation) Mild-to-moderate: No dosage adjustment required Serum creatinine ?1.5 mg/dL: Decrease dose to 2.5 mg BID if patient has 1 additional characteristic of age ?80 years or weight ?60 kg ESRD maintained on hemodialysis: 5 mg BID; decrease dose to 2.5 mg BID if 1 additional characteristic of age ?80 years or weight ?60 kg is present

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Apixaban may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Apixaban, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Epistaxis, haematoma, anaemia, haematuria, contusion, nausea; GI, rectal or gingival haemorrhage. Potentially Fatal: Epidural or spinal haematoma, fatal bleeding.

[SAFE] Apixaban does not usually affect your ability to drive. For best results, take Apixaban at the same time every day. It is better to take at night with meals It interacts less with food or other medicines. Hence, frequent dose changes are not required. It increases your risk of bleeding. Be careful while shaving, cutting fingernails or toenails, using sharp objects or engaging in contact sports (e.g. football, wrestling). Inform your doctor if you see blood in your vomit, urine or stool (black, tarry stools or bright red blood). If you are going to have a surgery or dental treatment, you may be asked to stop taking Apixaban temporarily. Notify your doctor if you have any kidney problem. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding. Do not stop taking medication without talking to your doctor.

Hypersensitivity. Clinically significant active bleeding. Hepatic disease associated w/ coagulopathy & clinically relevant bleeding risk. Lesion or condition at significant risk of major bleeding. Concomitant treatment w/ other anticoagulant agent.

Increased exposure w/ strong dual CYP3A4 and P-glycoprotein (P-gp) inhibitors (e.g. clarithromycin, itraconazole, ketoconazole, ritonavir). Increased risk of bleeding w/ drugs affecting haemostasis (e.g. aspirin, heparin, fibrinolytics, SSRIs, NSAIDs, serotonin norepinephrine reuptake inhibitors). Increased risk of stroke w/ strong dual CYP3A4 and P-gp inducers (e.g. rifampicin, phenytoin, carbamazepine).

[CAUTION] Caution is advised when consuming alcohol with Apixaban. Please consult your doctor.

[SAFE IF PRESCRIBED] Apixaban is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

[CONSULT YOUR DOCTOR] Apixaban is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[CAUTION] Apixaban should be used with caution in patients with kidney disease. Dose adjustment of Apixaban may be needed. Please consult your doctor. [CAUTION] Apixaban should be used with caution in patients with liver disease. Dose adjustment of Apixaban may be needed. Please consult your doctor. Dose adjustment is not needed in patients with the mild liver disease.

Deep vein thrombosis , swelling nd painful in both leg. You need to take a surgical consultation Looking for a specialist in Deep vein thrombosis preferably in Kochi See a vascular surgeon Liquid 5 mg is too costly.could u suggest any other medicine in same formula?please help me. Sit by mistake medicine name is eliquis 5mg Same meds not available but other cheaper substitute is there talk to ur In road accident head and small intestine got injured . 15 stiches on head and operation of 1 inch diameter of intestine . Now spo2 level is dropping to 70% after 1 hour of removing oxygen mask Get checked for pulmonary embolism or pneumothorax GE my self v.k tiwari mbbs md i feel the patient information above is there any blood test for diagnosed pulmonary edema and pulmonary embolism Dear Sir There is no specific blood test for diagnosing pulmonary edema and embolism Thrombosis involving both main pulmonary arteries and branches . Sir the patent has been chest pain with thrombosis pulmonary in both arteries n branch So what is the solution n treatment for this patent Need to see you in person.can meet me at medanta.call 9XXXXXX Hiii my wife having hurt patient ( pulmonary hypertension ) she&#x27;s taking pulmonext 5mg tablet but this tablet is very costly for me of Rs. 1450/- 10tab. I want to know any another tablet available in same drugs with low price This can&#x27;t be decided online Your doctor is the best judge about your patients pulmonary hypertension I am suffering from pulmonary embolism. I want to know will i die because of this disease ? What is d extent of your disease