osudhkosh
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Company•Square Pharmaceuticals PLC.

Prazolok ER 2.5

Rx
Generic: Prazosin Hydrochloride

৳ 10/unit

Pack: ৳ 100

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At a glance

Prazosin Hydrochloride is an alpha-blocker used for the treatment of hypertension, left ventricular failure, Raynaud's phenomenon, and benign prostatic hyperplasia. It lowers blood pressure by blocking postsynaptic α1-adrenoceptors, causing vasodilation.

Indications
  • Hypertension (primary and secondary)
  • Left ventricular failure
  • Raynaud's phenomenon and Raynaud's disease
  • Benign prostatic hyperplasia (BPH)
Pharmacology

Prazosin blocks postsynaptic α1-adrenoceptors in vascular smooth muscle, decreasing total peripheral vascular resistance. It lowers blood pressure, reduces left ventricular filling pressure, and increases cardiac output. In prostatic and urethral smooth muscle, it improves BPH symptoms by blocking α1-receptors.

Dosage

Adult Dose (Oral):

  • Hypertension: Initial 0.5 mg 2-3 times daily (3-7 days); 1 mg 2-3 times daily (next 3-7 days); maintenance up to 15 mg/day in divided doses; max 20 mg/day
  • BPH: Initial 0.5 mg twice daily; maintenance up to 2 mg twice daily
  • Raynaud's: 1-5 mg every 12 hours
  • Elderly and hepatic impairment: Dose reduction needed
  • XR tablet: 2.5 mg once daily initially; gradually increase to 20 mg/day
Side effects

Common Side Effects:

  • Dizziness
  • Headache
  • Drowsiness
  • Lack of energy
  • Weakness
  • Palpitations
  • Nausea
  • Orthostatic hypotension
Use in pregnancy

Use in Pregnancy: May be unsafe during pregnancy; animal studies have shown harmful effects; consult your doctor.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • May affect driving ability; do not drive if drowsy or dizzy
  • Risk of postural hypotension with first dose; start with low dose
  • Avoid alcohol (may enhance hypotensive effect)
  • Inform doctor before cataract surgery
  • Caution in pregnancy and lactation
Overdose effects

Overdose (≥50 mg): Profound drowsiness, depressed reflexes; if hypotension occurs, place patient supine, volume expanders, vasopressors if needed; prazosin is not dialyzable (protein-bound).

Storage conditions

Keep away from light and moisture, store below 30°C; keep out of reach of children.

Prazosin Hydrochloride — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.