৳ 800/unit
Pack: ৳ 800
৳ 800/unit
Pack: ৳ 800
At a glance
Conjugated Oestrogens is a female sex hormone (estrogen) used as part of hormone replacement therapy for estrogen deficiency symptoms (hot flashes, vaginal dryness) and prevention of postmenopausal osteoporosis.
Indications
- Menopausal Vasomotor Symptoms (hot flashes)
- Atrophic Vaginitis/Kraurosis Vulvae
- Female Hypogonadism
- Osteoporosis Prophylaxis
- Prostate Cancer (Palliation)
- Breast Cancer (Palliation)
- Abnormal Uterine Bleeding
Pharmacology
Estrogens modulate pituitary secretion of gonadotropins, luteinising hormones and follicle-stimulating hormones through negative feedback mechanism, thus reducing elevated levels of hormones in postmenopausal women during estrogen replacement therapy.
Dosage
Adult Dose (Oral):
| Indication | Dose | Schedule |
|---|---|---|
| Menopausal Vasomotor Symptoms, Atrophic Vaginitis | 0.3 mg | Once daily (continuous or cyclic: 25 days on, 5 days off) |
| Female Hypogonadism | 0.3-0.625 mg | Cyclic (3 weeks on, 1 week off) |
| Osteoporosis Prophylaxis | 0.3 mg | Cyclic (25 days on, 5 days off) or daily |
| Prostate Cancer (Palliation) | 1.25-2.5 mg | Every 8 hours |
| Breast Cancer (Palliation) | 10 mg | Every 8 hours (>3 months) |
| Abnormal Uterine Bleeding | 25 mg (IV/IM) or 10-20 mg/day | As needed or every 4 hours |
Side effects
Common Side Effects:
- Bloating
- Breast pain
- Hair loss
- Headache
- Irregular vaginal bleeding
- Nausea
- Stomach cramp
- Vomiting
- Vaginal discharge changes
Serious Side Effects: Breast cancer, blood clots (DVT, PE), stroke, heart attack, gallbladder disease, dementia.
Use in pregnancy
[CONSULT YOUR DOCTOR] Conjugated Oestrogens is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. Pregnancy Category X.
Pregnancy Category: X — always consult a doctor before taking during pregnancy.
Precautions & warnings
- You have been prescribed Conjugated Oestrogens as a part of hormone replacement therapy to relieve symptoms of menopause.
- Take it at the same time everyday to help you remember to take it.
- Inform your doctor if you experience any unusual vaginal bleeding or spotting, abnormal vaginal discharge or vaginal discomfort.
- It may increase the risk of breast cancer. Have regular breast examinations.
- Stop taking this medicine and inform your doctor immediately if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, or changes in vision (could be symptoms of a blood clot).
- Contraindicated during pregnancy.
Overdose effects
Conjugated Oestrogens overdose symptoms include nausea, vomiting, breast tenderness, dizziness, abdominal pain, and fatigue. Withdrawal bleeding may occur. Treatment is symptomatic and supportive.
Storage conditions
Store in a cool and dry place, away from light and out of reach of children.