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Pyrazinamide is an antibiotic that belongs to a class of medicines known as anti tuberculosis drugs. It is used in the treatment of tuberculosis, an infectious disease that mainly affects the lungs and in some cases other parts of the body. Pyrazinamide is given in combination with at least one other tuberculosis medicine. It acts by killing the causative bacteria. It should be used in the dose and duration as advised by your doctor. This medicine may be taken with or without food, preferably at a fixed time every day to avoid a missed dose. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early can result in treatment failure and increase the side effects too. Please let your doctor know about any changes in your weight as the dose of this medicine depends on the overall body weight of a person. Any changes in weight might need dose modification. If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose, as it may increase the side effects. Inform your doctor if you notice signs of jaundice i.e. yellowing of eyes or skin, dark urine, stomach pain or joint pain. You may also develop hepatitis (viral infection of the liver), increased liver enzymes and joint pain as side effects of this medicine. Please consult your doctor, as these side effects require medical attention and might need dose modification. Your doctor may monitor your liver function while on treatment with this medicine. Avoid drinking alcohol as this may have additional adverse effects on the liver. Pregnant or breastfeeding women should consult their doctor before using this medicine. Pyrazinamide is an antitubercular medicine. In the body, it gets converted to pyrazinoic acid. This pyrazinoic acid inhibits fatty acid synthase I (bacterial enzyme), which is essential for bacterial growth. Thus, it works as a bacteriocidal to prohibit their growth and treats tuberculosis.

• Tuberculosis (TB)

Pyrazinamide may be bacteriostatic or bactericidal in action, depending on the concentration of the drug attained at the site of the infection and the susceptibility of the infecting organism. Its activity appears to partly depend on conversion of the drug to pyrazinoic acid (POA), which lowers the pH of the environment below that which is necessary for growth of Mycobacterium tuberculosis. Susceptible strains of M. tuberculosis produce pyrazinamidase, an enzyme that deaminates pyrazinamide to POA, and the in vitro susceptibility of a given strain of the organism appears to correspond to its pyrazinamidase activity.

Adult Dose: Oral Tuberculosis Adult: As part of a multidrug regimen: For standard unsupervised 2-mth treatment: 50 kg: 2 g daily. For intermittent supervised 2-mth treatment: 50 kg: 2.5 g 3 times wkly. Hepatic impairment: Severe: Contraindicated. Child Dose: Oral Tuberculosis Child: As part of a multidrug regimen: For standard unsupervised 2-mth treatment: 35 mg/kg daily. For intermittent supervised 2-mth treatment: 50 mg/kg 3 times wkly. Renal Dose: Renal impairment: May need dose reduction.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pyrazinamide may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Pyrazinamide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Jaundice • Hepatitis (viral infection of liver) • Increased liver enzymes • Joint pain

[CONSULT YOUR DOCTOR] It is not known whether Pyrazinamide alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Pyrazinamide along with other medications effectively treats tuberculosis. Do not to forget a dose, as this increases the risk of the bacteria becoming resistant to the medicine, and also increases the risk of getting side effects. Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain. Avoid drinking alcohol while taking Pyrazinamide as this may increase the risk of side effects on the liver. Use a reliable contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking Pyrazinamide as it may make hormonal contraceptives such as the pill less effective.

Hypersensitivity; existing liver disease; acute gout or hyperuricaemia. Porphyria. Pregnancy and lactation.

Antagonises the effect of uricosuric agents (e.g. probenecid, sulfinpyrazone). May reduce the contraceptive effect of oestrogens. May inactivate oral typhoid vaccine. May increase the serum concentration of ciclosporin. May enhance the hepatotoxic effect of rifampicin.

[CAUTION] Caution is advised when consuming alcohol with Pyrazinamide. Please consult your doctor.

[CONSULT YOUR DOCTOR] Pyrazinamide may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Pyrazinamide is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[CAUTION] Pyrazinamide should be used with caution in patients with severe kidney disease. Dose adjustment of Pyrazinamide may be needed. Please consult your doctor. Kidney function tests are advised before you start taking this medicine. [CAUTION] Pyrazinamide should be used with caution in patients with liver disease. Dose adjustment of Pyrazinamide may be needed. Please consult your doctor. Regular monitoring of liver function tests is advised before and after the start of the treatment.

My daughter is given tb medicine even though she is not infected taking these medicine will cause tb??? Hello, TB medicines are given only when there is indication of tuberculosis. They are for treating tuberculosis. Though took vaccines in childhood, the test for TB came positive. Was advised to undergo treatment.physically absolute fit and healthy, is it advisable to take treatment? If sputum is positive for Tb , treatment is absolutely essential. Read more at www.arohealth.com/tuberculosis Extra pulmonary tuberculosis mdr tb for spinal card treatment This needs to be examined and treated in the clinic I had ectopic pregnancy as advice by dr.I had gone for laparoscopy for my other tube and after dat she gave me this medication ISONIAZID, PYRAZINAMIDE 750mg,PYRICO TIN, COMBUTOL600 which I had checked online dis all tablets r for TB so should I continue or stop If u have been diagnosed with tuberculosis then start otherwise not Whats r Various pathological test for me tuberculosis???? Dear PATIENT various tests which you use for MDR Tuberculosis are: Genexpert test which basically detects the DNA of TB bacteria, microarrays, Phage assyas etc. Sir my aunt has lymph node tuberculosis she had all the TB medicine course completely but no cure plzz prescribe her effective ayurvadic medice of lymph node tuberculosis Kindly send your reports on E-mail at : Fluid in lungs, in fluid sample tuberculosis positive any solution? Sir if TB is positive the best treatment is to take Anti Tuberculosis Treatment (ATT) from GOVT authorised ATT centres. But you can also add homeopathy for improvement in general health. I have cough problem from 25 days. I used penther syrup, tuspel cough syrup and tuff DMR , DMR 20 tablet, Roxud 150 mg but no much recovery so prescribe me for that. refer to chest specialist and do test for tuberculosis