Rasilez HCT 150/12.5
TabletRx৳ 1/unit
Pack: ৳ 1
৳ 1/unit
Pack: ৳ 1
At a glance
Aliskiren Hemifumarate + Hydrochlorothiazide is a fixed-dose combination medicine used for the treatment of essential hypertension in adults. Aliskiren is a direct renin inhibitor, and hydrochlorothiazide is a thiazide diuretic.
Indications
Essential hypertension in adults, particularly in patients whose blood pressure is not adequately controlled on aliskiren or hydrochlorothiazide alone [citation:1][citation:4][citation:5].
Pharmacology
Aliskiren is a potent, selective, orally active direct renin inhibitor that inhibits the enzyme renin, preventing the conversion of angiotensinogen to angiotensin I [citation:2][citation:3]. This reduces angiotensin II (a potent vasoconstrictor) and aldosterone levels, lowering blood pressure [citation:1][citation:2][citation:5]. Unlike ACE inhibitors or ARBs, aliskiren decreases plasma renin activity (PRA) [citation:2][citation:3][citation:6]. Hydrochlorothiazide is a thiazide diuretic that inhibits the Na+-Cl- symporter in the distal convoluted tubule, increasing sodium and chloride excretion [citation:2][citation:3][citation:6]. This reduces plasma volume and lowers blood pressure [citation:1][citation:3][citation:5].
Dosage
Adults:
- Usual starting dose: 150/12.5 mg once daily [citation:4]
- May be titrated up to maximum 300/25 mg once daily as needed [citation:4]
Side effects
Common side effects:
- Diarrhea – most common side effect of aliskiren [citation:1][citation:5]
- Dizziness
- Joint pain
- Cough [citation:1][citation:5]
- Fatigue
- Increased blood potassium levels
- Gastrointestinal irritation, weakness, headache (from hydrochlorothiazide) [citation:1][citation:5]
Serious (rare): Angioedema (rare with aliskiren) [citation:1][citation:5]
Use in pregnancy
Pregnancy Category: D
Aliskiren + Hydrochlorothiazide is highly unsafe during pregnancy. Drugs acting on the renin-angiotensin system can cause fetal and neonatal morbidity and death [citation:6]. Discontinue immediately if pregnancy is detected [citation:3][citation:4][citation:6].
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Pregnancy: Highly unsafe (Category D). Discontinue immediately if pregnancy is detected [citation:3][citation:4][citation:6]
- Severe renal impairment: Not recommended [citation:3]
- Diabetes with renal impairment (GFR <60 mL/min): Avoid concomitant use with ACE inhibitors or ARBs
- History of angioedema: Caution required
- Volume depletion/dehydration: Not recommended as initial therapy [citation:4]
- Electrolyte imbalance: Regular monitoring required
Overdose effects
Overdose symptoms: electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration from excessive diuresis [citation:6]. Treatment: symptomatic and supportive measures.
Storage conditions
Store below 30°C in a cool and dry place, protected from light. Keep out of reach of children.