৳ 200/unit
Pack: ৳ 2,000
৳ 200/unit
Pack: ৳ 2,000
At a glance
Regorafenib is a multi-kinase inhibitor used for metastatic colorectal cancer (CRC), locally advanced unresectable or metastatic gastrointestinal stromal tumor (GIST), and hepatocellular carcinoma (HCC) after prior therapy failure.
Indications
- Metastatic colorectal cancer (after fluoropyrimidine, oxaliplatin, irinotecan-based chemotherapy, anti-VEGF therapy, and anti-EGFR therapy for RAS wild-type)
- Locally advanced unresectable or metastatic GIST (after imatinib and sunitinib)
- Hepatocellular carcinoma (after sorafenib)
Pharmacology
Regorafenib inhibits multiple kinases involved in tumor growth, angiogenesis, and metastasis. It inhibits RET, VEGFR1/2/3, KIT, PDGFR, FGFR, RAF-1, BRAF, and other kinases. It demonstrates anti-angiogenic and anti-metastatic activity in animal models.
Dosage
Adult Dose (Oral):
- Recommended dose: 160 mg (four 40 mg tablets) once daily for the first 21 days of each 28-day cycle
- Take with a low-fat meal (<600 calories, <30% fat) and swallow whole with water
- Dose modifications: Reduce in 40 mg increments; lowest recommended dose 80 mg daily
Side effects
Side Effects:
- Hepatotoxicity
- Infections
- Hemorrhage
- Gastrointestinal perforation or fistula
- Hand-foot skin reaction (HFSR)
- Hypertension
- Cardiac ischemia and infarction
- Reversible Posterior Leukoencephalopathy Syndrome (RPLS)
Use in pregnancy
Use in Pregnancy: No data on use in pregnant women; advise of potential risk to the fetus.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Hepatotoxicity: Monitor LFT every 2 weeks during first 2 months; withhold, reduce, or discontinue for severe toxicity
- Hemorrhage: Permanently discontinue for severe or life-threatening hemorrhage; monitor INR in patients on warfarin
- GI perforation/fistula: Permanently discontinue
- Hypertension: Control blood pressure; monitor weekly for first 6 weeks
- Wound healing: Discontinue at least 2 weeks before surgery
- Embryo-fetal toxicity: Use effective contraception
Overdose effects
Overdose (highest studied 220 mg/day): Dermatological events, dysphonia, diarrhea, mucosal inflammation, dry mouth, decreased appetite, hypertension, fatigue; no specific antidote; discontinue, supportive care, observe.
Storage conditions
Store below 30°C in a cool and dry place, away from sunlight; keep out of reach of children.