Repane
0.40%Rx৳ 200/unit
Pack: ৳ 200
৳ 200/unit
Pack: ৳ 200
At a glance
Glyceryl Trinitrate 0.4% (nitroglycerine) Rectal prep is used for the treatment of anal fissure.
Indications
- Anal fissure
Pharmacology
Glyceryl trinitrate acts on the enzyme nitric oxide stimulating guanylate cyclase in the vascular smooth muscle cells resulting in the relaxation of smooth muscles. Rectal application relaxes the sphincter muscle, relieves pain from anal fissure and promotes healing by improving blood flow.
Dosage
Adult Dose (Rectal):
- As 0.4% ointment for anal fissure: Apply 1.5 mg 12 hourly
- Up to 8 weeks
Side effects
Common Side Effects:
- Headache (common)
Use in pregnancy
Use in Pregnancy: Generally considered safe during pregnancy. Animal studies have shown low or no adverse effects.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Headache usually goes away after a few days - inform doctor if it persists.
- May cause dizziness or sleepiness - do not drive.
- Avoid alcohol (increases dizziness).
- Do not use with sildenafil or tadalafil (may cause hypotension).
Overdose effects
Overdose: Overuse may cause severe headache, dizziness, hypotension. Discontinue use and seek medical attention.
Storage conditions
Storage: Keep below 30°C, away from light. Keep out of reach of children.