৳ 2.50/unit
Pack: ৳ 25
৳ 2.50/unit
Pack: ৳ 25
At a glance
Risperidone is an atypical antipsychotic used for schizophrenia, mania, and irritability associated with autism. Its activity is mediated through a combination of dopamine (D2) and serotonin (5-HT2) receptor antagonism.
Indications
- Acute and chronic psychoses
- Mania
- Schizophrenia
- Irritability associated with autism (5-16 years)
Pharmacology
Risperidone blocks serotonin 5-HT2 and dopamine D2 receptors. As a potent D2 antagonist, it improves positive symptoms of schizophrenia but causes less depression of motor activity. Balanced serotonin and dopamine antagonism may reduce extrapyramidal side effects and extend therapeutic activity to negative and affective symptoms.
Dosage
Adult Dose (Oral):
- Psychoses: Day 1: 2 mg (1-2 divided doses); Day 2: 4 mg; maintenance: 4-6 mg/day; max 16 mg/day
- Schizophrenia: 1 mg twice daily initially; titrate to 3 mg twice daily target
- Mania: 2 mg/day initially; maintenance 1-6 mg/day
- Elderly/hepatic/renal impairment: 1 mg/day initially in 2 divided doses
- Tourette syndrome: 0.5-1 mg/day; up to 6 mg/day
- PTSD: 0.5-8 mg/day
Pediatric Dose (Oral):
- Schizophrenia (≥13 years): 0.5 mg/day; up to 3 mg/day; 1-6 mg/day
- Mania (≥10 years): 0.5 mg/day; up to 2.5 mg/day; 0.5-6 mg/day
- Autism irritability (5-16 years, >20 kg): 0.5 mg/day; up to 1 mg/day
Side effects
Side Effects:
- Dizziness
- Sleepiness
- Orthostatic hypotension
- Dry mouth
- Weight gain
- Constipation
- Muscle stiffness
- Restlessness
- Tremor
- Hyperprolactinemia
- Insomnia, anxiety, headache
Use in pregnancy
Use in Pregnancy: May be unsafe during pregnancy; animal studies have shown harmful effects; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May affect driving ability; do not drive if drowsy or dizzy
- Discontinue if Neuroleptic Malignant Syndrome (fever, muscle rigidity, altered consciousness) occurs
- Rise slowly to avoid orthostatic hypotension
- May cause weight gain, increased blood sugar and cholesterol; monitor regularly
- Do not stop abruptly
- Risk of suicidal thoughts or behavior; monitor
Overdose effects
No overdose information available; consult your doctor if taken in excess.
Storage conditions
Do not store above 30°C; keep away from light; keep out of reach of children.