Rezoven10mg

Adefovir Dipivoxil is a diester prodrug of adefovir, an acyclic nucleotide analog with potent activity against hepatitis B virus (HBV) by inhibiting viral DNA synthesis.

Treatment of chronic hepatitis B in adults with evidence of active viral replication and elevated serum aminotransferases (ALT or AST) or histologically active disease.

Hepatic viral infections (Hepatitis B)

Nucleotide Reverse Transcriptase Inhibitor (NtRTI)

Adefovir dipivoxil is converted intracellularly to adefovir diphosphate. It competitively inhibits HBV DNA polymerase (reverse transcriptase) and causes termination of the viral DNA chain. Oral bioavailability is ~59% and renal excretion is the primary elimination route.

Inhibits HBV DNA polymerase by competing with natural deoxyadenosine triphosphate and inducing DNA chain termination after incorporation into viral DNA.

Adults (normal renal function): 10 mg once daily. Renal Impairment: CrCl 20-49 mL/min: 10 mg every 48 hours; CrCl 10-19 mL/min: 10 mg every 72 hours; Hemodialysis: 10 mg every 7 days post-dialysis.

For oral use. Administer once daily with or without food.

Take as soon as remembered unless it is almost time for the next dose. Do not double the dose.

Common: Asthenia, headache, abdominal pain, nausea. Serious: Nephrotoxicity, severe acute exacerbation of hepatitis B upon discontinuation, lactic acidosis, and hepatomegaly with steatosis.

Monitor renal function closely in at-risk patients and adjust dose. Perform periodic liver function monitoring post-discontinuation.

Known hypersensitivity to adefovir dipivoxil or any component of the formulation.

Coadministration with ibuprofen (800 mg tid) increases adefovir AUC by 23% and Cmax by 33%. No significant interactions with lamivudine, TMP-SMX, or acetaminophen.

Can be taken without regard to food.

Pregnancy Category C. Use during pregnancy only if potential benefit justifies potential risk to fetus.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Excretion in human milk is unknown. Mothers should be instructed not to breastfeed while taking adefovir dipivoxil.

Safety and effectiveness in pediatric patients have not been established.

Use with caution in elderly patients due to higher prevalence of decreased renal or cardiac function.

Dose interval adjustment required based on baseline creatinine clearance. Monitor liver function upon discontinuation.

High doses (250-500 mg daily) cause gastrointestinal adverse effects. Provide supportive and symptomatic treatment.

Store at a cool, dry place protected from light and moisture. Keep out of reach of children.

Adefovir Dipivoxil (C14H21N5O8P)

Question: What is Adefovir Dipivoxil used for? Answer: It is an antiviral medication indicated for the treatment of chronic hepatitis B in adults with evidence of active viral replication. Question: How should Adefovir Dipivoxil be taken? Answer: The recommended dose for patients with adequate renal function is 10 mg once daily, taken orally with or without food. Question: What happens if the medication is stopped abruptly? Answer: Discontinuing treatment without medical advice can lead to severe acute exacerbations of hepatitis B. Question: Does it require dosage adjustment in patients with kidney impairment? Answer: Yes, dosing intervals must be adjusted for patients with baseline creatinine clearance (CrCl) less than 50 mL/min.