৳ 20.07/unit
Pack: ৳ 401.40
৳ 20.07/unit
Pack: ৳ 401.40
At a glance
Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic used for traveler's diarrhea, reduction in risk of overt hepatic encephalopathy, and bacterial overgrowth of irritable bowel syndrome.
Indications
- Traveler's diarrhea (E. coli)
- Reduction in risk of overt hepatic encephalopathy
- Bacterial overgrowth of irritable bowel syndrome
Pharmacology
Rifaximin is a non-systemic antibiotic that works locally in the GI tract. It inhibits bacterial RNA synthesis by binding to the beta-subunit of DNA-dependent RNA polymerase. With minimal absorption, it is effective against intestinal bacteria without systemic side effects.
Dosage
Adult Dose (Oral):
- Traveler's diarrhea: 200 mg every 8 hours for 3 days
- Hepatic encephalopathy maintenance: 550 mg every 12 hours
- IBS-D: 550 mg every 8 hours for 14 days; may repeat up to 2 times
- Bacterial overgrowth: 400 mg 3 times daily for 10 days OR 550 mg 3 times daily for 14 days
Pediatric Dose (≥12 years):
- Traveler's diarrhea: 200 mg every 8 hours for 3 days
Side effects
Side Effects:
- Flatulence
- Headache
- Abdominal pain
- Rectal tenesmus
- Defecation urgency
- Nausea
- Constipation
- Pyrexia
- Vomiting
- Anaphylaxis (rare)
Use in pregnancy
Use in Pregnancy: May be unsafe during pregnancy; animal studies have shown harmful effects; Pregnancy Category C; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Not effective in diarrhea complicated by fever and/or blood in stools
- Discontinue if no improvement or worsening within 24-48 hours
- Pseudomembranous colitis may occur
- Caution in pregnancy and lactation
Overdose effects
Overdose: No specific information; discontinue, treat symptomatically and institute supportive measures as required.
Storage conditions
Keep below 30°C, away from light and moisture; keep out of reach of children.