Riluzol 50

Riluzole is a prescription medicine used in the treatment of amyotrophic lateral sclerosis (ALS), a degenerative disease that weakens muscles and hence affects the overall physical function. Riluzole modifies the action of glutamate, a chemical messenger involved in the transmission of nerve signals in the brain. This medicine is taken on an empty stomach, either 1 hour before or 2 hours after meals. If you have missed a dose, take it as soon as you remember. Do not skip any doses and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to your doctor. Some common side effects of using this medication are weakness, headache, nausea and stomach pain. It may also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. This medicine may cause diarrhea, so drink plenty of fluids to keep yourself hydrated while taking this medicine. Avoid alcohol while taking this medicine as it may increase the dizziness further. Your doctor may advise for liver and kidney function tests while taking this medicine. It is advised to reduce smoking or even better, to stop it as this may help to provide better results. Riluzole is a glutamate antagonist and used an an anticonvulsant (anti fits). It is believed to work by inhibiting the action of glutamate (chemical messenger) and also inactivates the voltage-dependent sodium channels. In this way it regulates the transmission of nerve signals in the brain.

• Amyotrophic lateral sclerosis (ALS)

Riluzole is a glutamate inhibitor used to slow disease progression and prolong survival rate in patients with amyotrophic lateral sclerosis. The exact mechanism of its action is not fully elucidated but is shown to inhibit the release of glutamate, inactivate voltage-dependent Na channels, and interfere with intracellular events following binding of transmitter at excitatory amino acid receptors.

Adult Dose: Oral Amyotrophic lateral sclerosis Adult: 50 mg bid. Discontinue if ALT levels increase to 5 times the upper limit of normal (ULN). Hepatic impairment Mild or moderate (Child-Pugh A or B): Patients had increases in AUC; thus, may be at increased risk of adverse reactions Severe (Child-Pugh C): Unknown Not recommended for patients with baseline serum aminotransferases (AST/ALTs) >5x ULN or evidence of liver dysfunction (eg, elevated bilirubin)

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Riluzole is to be taken empty stomach. Avoid Riluzole with high-fat meals such as olive oil, nuts & seeds (Brazil nuts), dark chocolate, butter and meat.

Common: • Weakness • Headache • Dizziness • Nausea • Abdominal pain • Diarrhea • Decreased pulmonary function • Paresthesia (tingling or pricking sensation) • Sleepiness • Increased heart rate • Vomiting • Pain • Abnormal liver function tests

[UNSAFE] Riluzole may cause side effects which could affect your ability to drive. You may feel dizzy or light headed after taking this medicine. This may affect your driving ability. Take it twice a day, 1 hour before or 2 hours after the meal, preferably at the same time. It may cause sleepiness. Don't drive or do anything requiring concentration until you know how it affects you. Avoid smoking as it may make Riluzole less effective. Your doctor may monitor your liver function, lung function and blood count while you are taking this medicine. Inform your doctor if you develop yellowing of the skin, abdominal pain, fever, sore throat, new cough or shortness of breath while taking this medicine. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Hepatic impairment (baseline transaminases >3 times the upper limit of normal).

Decreased rate of elimination with CYP1A2 inhibitors (e.g. caffeine, ciprofloxacin, oral contraceptives). Increased rate of elimination with CYP1A2 inducers (e.g. rifampicin, omeprazole). Increased risk of hepatotoxicity with hepatotoxic drugs (e.g. allopurinol, methyldopa, sulfasalazine).

[CAUTION] Caution is advised when consuming alcohol with Riluzole. Please consult your doctor.

[CONSULT YOUR DOCTOR] Riluzole may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Riluzole is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[CONSULT YOUR DOCTOR] There is limited information available on the use of Riluzole in patients with kidney disease. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Riluzole in patients with liver disease. Please consult your doctor.

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