osudhkosh
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Company•Renata Limited

Riluzol 50

Rx
Generic: Riluzole

৳ 150/unit

Pack: ৳ 1,500

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At a glance

Riluzole is a glutamate inhibitor used to slow disease progression and prolong survival in patients with amyotrophic lateral sclerosis (ALS). It inhibits glutamate release, inactivates voltage-dependent Na channels, and interferes with intracellular events following transmitter binding at excitatory amino acid receptors.

Indications
  • Amyotrophic lateral sclerosis (ALS) - to extend life or delay time to mechanical ventilation
Pharmacology

Riluzole inhibits glutamate release, inactivates voltage-dependent Na channels, and interferes with intracellular events following transmitter binding at excitatory amino acid receptors. It is neuroprotective and exhibits anticonvulsant and myorelaxant properties in animal models.

Dosage

Adult Dose (Oral):

  • ALS: 50 mg twice daily
  • Take at least 1 hour before or 2 hours after meals
  • Discontinue if ALT levels increase to 5 times ULN
  • Hepatic impairment (mild-moderate): Increased AUC; risk of adverse reactions
  • Severe hepatic impairment: Unknown; not recommended
Side effects

Common Side Effects:

  • Weakness
  • Headache
  • Dizziness
  • Nausea
  • Abdominal pain
  • Diarrhea
  • Decreased pulmonary function
  • Paresthesia
  • Sleepiness
  • Tachycardia
  • Abnormal liver function tests
Use in pregnancy

Use in Pregnancy: May be unsafe during pregnancy; animal studies have shown harmful effects; consult your doctor; contraindicated in pregnancy.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Monitor liver function; measure ALT before and during therapy; monthly for first 3 months, then every 3 months
  • Smoking reduces riluzole efficacy; quit smoking
  • May affect driving ability; do not drive if dizziness or vertigo occurs
  • Neutropenia: Report febrile illness; discontinue if neutropenia occurs
  • Interstitial lung disease: Discontinue if occurs
Overdose effects

No overdose information available; consult your doctor if taken in excess.

Storage conditions

Store in a cool and dry place, protected from light; do not store above 30°C.

Riluzole — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.