৳ 30/unit
Pack: ৳ 300
৳ 30/unit
Pack: ৳ 300
At a glance
Primidone, used alone or with other anticonvulsants, is indicated for the control of grand mal, psychomotor, and focal epileptic seizures. It may control grand mal seizures refractory to other anticonvulsant therapy.
Indications
- Grand mal seizures
- Psychomotor seizures
- Focal epileptic seizures
Pharmacology
Primidone raises electro- or chemoshock seizure thresholds in animal models. Primidone itself has anticonvulsant activity, as do its metabolites phenobarbital and PEMA. PEMA potentiates the anticonvulsant activity of phenobarbital.
Dosage
Adults and ≥8 years (Oral):
- Days 1-3: 100-125 mg at bedtime
- Days 4-6: 100-125 mg twice daily
- Days 7-9: 100-125 mg three times daily
- Day 10-maintenance: 250 mg three times daily
- Usual maintenance: 250 mg 3-4 times daily (max 500 mg four times daily)
- Maximum daily dose: 2 g
Side effects
Common Side Effects:
- Ataxia
- Vertigo
- Nausea
- Anorexia
- Vomiting
- Fatigue
- Hyperirritability
- Emotional disturbances
- Diplopia
- Nystagmus
- Drowsiness
- Morbilliform skin eruptions
- Granulocytopenia
- Agranulocytosis
- Aplastic anemia
- Megaloblastic anemia
Use in pregnancy
Use in Pregnancy: Effects in pregnancy unknown; animal studies have shown fetal abnormalities; use if potential benefit justifies potential risk.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Complete blood count and SMA-12 test every 6 months with prolonged therapy
- Substantial amounts excreted in breast milk; discontinue nursing if newborn shows undue somnolence
Overdose effects
Overdose: Ataxia, drowsiness, diplopia, nystagmus, coma, respiratory depression; treatment: gastric lavage, activated charcoal, supportive care.
Storage conditions
Store below 30°C, away from light and moisture; keep out of reach of children.