৳ 10.05/unit
Pack: ৳ 10.05
৳ 10.05/unit
Pack: ৳ 10.05
At a glance
Roflumilast is a PDE-4 inhibitor used to reduce exacerbations and symptoms of chronic obstructive pulmonary disease (COPD). It relaxes airway muscles and reduces inflammation by increasing cAMP in lung tissue, making breathing easier.
Indications
- Chronic Obstructive Pulmonary Disease (COPD) – reduction of exacerbations and symptoms
Pharmacology
Roflumilast selectively inhibits PDE-4, preventing cAMP breakdown and increasing intracellular cAMP in inflammatory cells (macrophages, neutrophils, eosinophils). This reduces the release of inflammatory mediators and relaxes airway smooth muscles, decreasing inflammation, bronchoconstriction, and COPD exacerbations.
Dosage
Adult Dose (Oral):
- COPD (exacerbation reduction): 500 mcg (0.5 mg) once daily
Side effects
Common Side Effects:
- Headache
- Weight loss
- Dizziness
- Insomnia
- Back pain
- Nausea and diarrhea
- Decreased appetite and flu-like symptoms
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies show harmful effects; use only if clearly needed; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Not for acute bronchospasm (sudden breathing attacks)
- Do not use in history of depression or suicidal thoughts/behavior
- Discontinue if unexplained and significant weight loss occurs
- Usually does not affect driving ability; avoid if dizzy
- Do not use in serious diseases like HIV, multiple sclerosis, lupus
Overdose effects
Limited overdose information; excessive doses may increase side effects; consult your doctor.
Storage conditions
Store in a cool and dry place, protected from light; keep out of reach of children.