৳ 7.02/unit
Pack: ৳ 7.02
৳ 7.02/unit
Pack: ৳ 7.02
At a glance
Roxithromycin is a macrolide antibiotic used to treat various bacterial infections of the respiratory tract, ENT, skin, and genital tract. It inhibits protein synthesis by binding to the 50S ribosomal subunit.
Indications
- Respiratory tract infections (pneumonia, bronchitis)
- ENT infections (tonsillitis, pharyngitis, sinusitis, otitis media)
- Skin infections (folliculitis, furuncles, cellulitis, impetigo)
- Genital infections (urethritis, prostatitis, cervicitis – especially Chlamydia trachomatis)
Pharmacology
Roxithromycin irreversibly binds to the 50S ribosomal subunit of bacteria, blocking transpeptidation or translocation reactions, resulting in stunted cell growth and preventing the infection from spreading.
Dosage
Adult Dose (Oral):
- Susceptible infections: 150 mg twice daily or 300 mg once daily (5-10 days)
- Severe hepatic impairment: 150 mg/day
Pediatric Dose (Oral):
- 6-11 kg: 25 mg every 12 hours
- 12-23 kg: 50 mg every 12 hours
- 24-40 kg: 100 mg every 12 hours
- Dose: 5-8 mg/kg/day (5-10 days)
Side effects
Common Side Effects:
- Nausea and vomiting
- Abdominal pain and diarrhea
- Allergic rash
- Dizziness and headache
- Dyspepsia, flatulence
- Tinnitus, vertigo, constipation
Use in pregnancy
Use in Pregnancy: Generally considered safe; animal studies show low or no adverse effects; limited human data; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Do not use in patients with a history of hypersensitivity to the drug
- In hepatic disease, dose should not exceed 150 mg twice daily
- May affect driving ability (drowsiness and dizziness)
- Safety in pregnancy not established
Overdose effects
Limited overdose information; excessive doses may increase side effects; consult your doctor.
Storage conditions
Store in a cool and dry place, protected from light; keep out of reach of children.