৳ 1,405.13/unit
Pack: ৳ 1,405.13
৳ 1,405.13/unit
Pack: ৳ 1,405.13
At a glance
Octreotide is a synthetic somatostatin analogue used for acromegaly, carcinoid tumors, VIPomas and variceal bleeding. It inhibits growth hormone and other hormone secretion and reduces bleeding by vasoconstriction.
Indications
- Acromegaly (inadequate response to surgery/radiation or unable to tolerate bromocriptine)
- Carcinoid tumors (severe diarrhea and flushing)
- VIPomas (VIP-secreting tumors)
- Esophageal variceal hemorrhage in cirrhosis
- Prophylaxis of complications following pancreatic surgery
- HIV-associated diarrhea
Pharmacology
Octreotide acts like somatostatin to inhibit growth hormone (GH), glucagon and insulin secretion. It suppresses LH response, reduces splanchnic blood flow, and inhibits various hormone secretions to control carcinoid symptoms and VIPoma diarrhea.
Dosage
Acromegaly (SC): 50 mcg 3 times daily (initial); titrate up to 500 mcg 3 times daily
Acromegaly (Depot IM): 20 mg every 4 weeks for 3 months; 10-30 mg every 4 weeks
Carcinoid Tumor (SC): 100-600 mcg/day in 2-4 divided doses; up to 1500 mcg/day
Carcinoid Tumor (Depot IM): 20 mg every 4 weeks
VIPomas: 200-300 mcg/day in 2-4 divided doses
Variceal Bleeding (IV): 25 mcg/hour for 48 hours (up to 5 days in high risk)
Pancreatic Surgery Prophylaxis: 100 mcg 3 times daily for 7 days
Side effects
Common Side Effects (>10%):
- Gallbladder abnormalities
- Sinus bradycardia
- Diarrhea
- Loose stools
- Nausea
- Abdominal discomfort
- Hyperglycemia
- Hypothyroidism
Use in pregnancy
Use in Pregnancy: Octreotide is safe during pregnancy (Category B); animal studies show low or no adverse effects.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Monitor gallbladder for stone formation
- Monitor glucose levels (hypo/hyperglycemia)
- Monitor thyroid function
- Monitor cardiac function (bradycardia, arrhythmias)
- Monitor vitamin B12 levels
Overdose effects
Overdose: Hypoglycemia, nausea, abdominal pain; symptomatic treatment.
Storage conditions
Store at 2-8°C; stable at room temperature for up to 14 days.